Overdominance

Overdominance is a phenomenon in genetics where the phenotype of the heterozygote lies outside the phenotypical range of both homozygous parents. Overdominance can also be described as heterozygote advantage regulated by a single genomic locus, wherein heterozygous individuals have a higher fitness than homozygous individuals. However, not all cases of the heterozygote advantage are considered overdominance, as they may be regulated by multiple genomic regions.^[1] Overdominance has been hypothesized as an underlying cause for heterosis (increased fitness of hybrid offspring).^[2]^[3]

^ Charlesworth, Deborah; Willis, John H. (November 2009). "The genetics of inbreeding depression". Nature Reviews Genetics. 10 (11): 783–796. doi:10.1038/nrg2664. ISSN 1471-0056. PMID 19834483. S2CID 771357.
^ Parsons, P. A.; Bodmer, W. F. (April 1961). "The Evolution of Overdominance: Natural Selection and Heterozygote Advantage". Nature. 190 (4770): 7–12. Bibcode:1961Natur.190....7P. doi:10.1038/190007a0. ISSN 0028-0836. PMID 13733020. S2CID 4223238.
^ Timberlake, W.E. (2013), "Heterosis", Brenner's Encyclopedia of Genetics, Elsevier, pp. 451–453, doi:10.1016/b978-0-12-374984-0.00705-1, ISBN 978-0-08-096156-9, retrieved 2022-11-04

[1] Charlesworth, Deborah; Willis, John H. (November 2009). "The genetics of inbreeding depression". Nature Reviews Genetics. 10 (11): 783–796. doi:10.1038/nrg2664. ISSN 1471-0056. PMID 19834483. S2CID 771357.

[2] Parsons, P. A.; Bodmer, W. F. (April 1961). "The Evolution of Overdominance: Natural Selection and Heterozygote Advantage". Nature. 190 (4770): 7–12. Bibcode:1961Natur.190....7P. doi:10.1038/190007a0. ISSN 0028-0836. PMID 13733020. S2CID 4223238.

[3] Timberlake, W.E. (2013), "Heterosis", Brenner's Encyclopedia of Genetics, Elsevier, pp. 451–453, doi:10.1016/b978-0-12-374984-0.00705-1, ISBN 978-0-08-096156-9, retrieved 2022-11-04

[1]

[2]

[3]