Oxytocin receptor

OXTR
Identifiers
Aliases	OXTR, OT-R, oxytocin receptor
External IDs	OMIM: 167055; MGI: 109147; HomoloGene: 20255; GeneCards: OXTR; OMA:OXTR - orthologs
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	112,466,904 bp
RNA expression pattern
	n/a
	Top expressed in
	mammary gland; ; lumbar subsegment of spinal cord; ; cervix; ; white adipose tissue; ; islet of Langerhans; ; ciliary body; ; pineal gland; ; mesenteric lymph nodes; ; dentate gyrus of hippocampal formation granule cell; ; adrenal gland;
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; peptide binding; signal transducer activity; peptide hormone binding; vasopressin receptor activity; oxytocin receptor activity;
Cellular component	integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; intracellular anatomical structure; microvillus; apical plasma membrane;
Biological process	response to cocaine; positive regulation of synapse assembly; positive regulation of norepinephrine secretion; response to cytokine; maternal process involved in parturition; response to estradiol; muscle contraction; response to anoxia; response to organic cyclic compound; eating behavior; ejaculation; estrous cycle; positive regulation of cytosolic calcium ion concentration; response to progesterone; response to amphetamine; ERK1 and ERK2 cascade; regulation of systemic arterial blood pressure by vasopressin; response to steroid hormone; response to peptide hormone; negative regulation of gastric acid secretion; memory; positive regulation of synaptic transmission, GABAergic; response to peptide; heart development; cell surface receptor signaling pathway; telencephalon development; sleep; cellular response to hormone stimulus; positive regulation of blood pressure; positive regulation of synaptic transmission, glutamatergic; maternal behavior; positive regulation of vasoconstriction; social behavior; positive regulation of penile erection; lactation; digestive tract development; regulation of digestive system process; signal transduction; positive regulation of uterine smooth muscle contraction; suckling behavior; female pregnancy; G protein-coupled receptor signaling pathway; positive regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	5021
	18430
	ENSG00000180914
	ENSMUSG00000049112
	P30559
	P97926
	NM_000916
	NM_001081147
	NP_000907; NP_001341582; NP_001341583; NP_001341584; NP_001341585
	NP_001074616
	Wikidata
View/Edit Human	View/Edit Mouse

The oxytocin receptor, also known as OXTR, is a protein which functions as receptor for the hormone and neurotransmitter oxytocin.^[4]^[5] In humans, the oxytocin receptor is encoded by the OXTR gene^[6]^[7] which has been localized to human chromosome 3p25.^[8]

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000049112 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gimpl G, Fahrenholz F (April 2001). "The oxytocin receptor system: structure, function, and regulation". Physiological Reviews. 81 (2): 629–83. doi:10.1152/physrev.2001.81.2.629. PMID 11274341. S2CID 13265083.
^ Zingg HH, Laporte SA (July 2003). "The oxytocin receptor". Trends in Endocrinology and Metabolism. 14 (5): 222–7. doi:10.1016/S1043-2760(03)00080-8. PMID 12826328. S2CID 21540056.
^ EntrezGene 5021
^ Kimura T, Tanizawa O, Mori K, Brownstein MJ, Okayama H (April 1992). "Structure and expression of a human oxytocin receptor" (PDF). Nature. 356 (6369): 526–9. Bibcode:1992Natur.356..526K. doi:10.1038/356526a0. PMID 1313946. S2CID 4273722. Archived from the original (PDF) on 2017-09-21. Retrieved 2021-05-29.
^ Simmons CF, Clancy TE, Quan R, Knoll JH (April 1995). "The oxytocin receptor gene (OXTR) localizes to human chromosome 3p25 by fluorescence in situ hybridization and PCR analysis of somatic cell hybrids". Genomics. 26 (3): 623–5. doi:10.1016/0888-7543(95)80188-R. PMID 7607693.
^ Koehbach J, Stockner T, Bergmayr C, Muttenthaler M, Gruber CW (February 2013). "Insights into the molecular evolution of oxytocin receptor ligand binding". Biochemical Society Transactions. 41 (1): 197–204. doi:10.1042/BST20120256. PMC 3634130. PMID 23356283.

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000049112 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11274341-4] Gimpl G, Fahrenholz F (April 2001). "The oxytocin receptor system: structure, function, and regulation". Physiological Reviews. 81 (2): 629–83. doi:10.1152/physrev.2001.81.2.629. PMID 11274341. S2CID 13265083.

[pmid12826328-5] Zingg HH, Laporte SA (July 2003). "The oxytocin receptor". Trends in Endocrinology and Metabolism. 14 (5): 222–7. doi:10.1016/S1043-2760(03)00080-8. PMID 12826328. S2CID 21540056.

[NCBI_Gene-6] EntrezGene 5021

[pmid1313946-7] Kimura T, Tanizawa O, Mori K, Brownstein MJ, Okayama H (April 1992). "Structure and expression of a human oxytocin receptor" (PDF). Nature. 356 (6369): 526–9. Bibcode:1992Natur.356..526K. doi:10.1038/356526a0. PMID 1313946. S2CID 4273722. Archived from the original (PDF) on 2017-09-21. Retrieved 2021-05-29.

[pmid7607693-8] Simmons CF, Clancy TE, Quan R, Knoll JH (April 1995). "The oxytocin receptor gene (OXTR) localizes to human chromosome 3p25 by fluorescence in situ hybridization and PCR analysis of somatic cell hybrids". Genomics. 26 (3): 623–5. doi:10.1016/0888-7543(95)80188-R. PMID 7607693.

[koechbach2013-9] Koehbach J, Stockner T, Bergmayr C, Muttenthaler M, Gruber CW (February 2013). "Insights into the molecular evolution of oxytocin receptor ligand binding". Biochemical Society Transactions. 41 (1): 197–204. doi:10.1042/BST20120256. PMC 3634130. PMID 23356283.

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