P-selectin

SELP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1FSB, 1G1Q, 1G1R, 1G1S, 1HES
Identifiers
Aliases	SELP, CD62, CD62P, GMP140, GRMP, LECAM3, PADGEM, PSEL, selectin P
External IDs	OMIM: 173610; MGI: 98280; HomoloGene: 2260; GeneCards: SELP; OMA:SELP - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q24.2 Start 169,588,849 bp[1] End 169,630,193 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 H2.2|1 71.42 cM Start 163,942,833 bp[2] End 163,977,595 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right coronary artery monocyte left uterine tube olfactory zone of nasal mucosa upper lobe of left lung gastric mucosa gallbladder left coronary artery canal of the cervix appendix Top expressed in endothelial cell of lymphatic vessel zygote secondary oocyte granulocyte primary oocyte blood embryo ankle joint tibiofemoral joint ankle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function heparin binding oligosaccharide binding lipopolysaccharide binding calcium-dependent protein binding glycosphingolipid binding fucose binding carbohydrate binding sialic acid binding protein binding calcium ion binding metal ion binding Cellular component integral component of membrane membrane platelet alpha granule membrane platelet dense granule membrane external side of plasma membrane extracellular space integral component of plasma membrane plasma membrane Biological process leukocyte cell-cell adhesion heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules positive regulation of leukocyte migration platelet degranulation regulation of integrin activation cell adhesion defense response to Gram-negative bacterium positive regulation of phosphatidylinositol 3-kinase signaling inflammatory response calcium-mediated signaling using intracellular calcium source positive regulation of platelet activation leukocyte migration response to lipopolysaccharide calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules leukocyte tethering or rolling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6403 20344 Ensembl ENSG00000174175 ENSMUSG00000026580 UniProt P16109 Q01102 RefSeq (mRNA) NM_003005 NM_011347 RefSeq (protein) NP_002996 NP_002996.2 NP_035477 Location (UCSC) Chr 1: 169.59 – 169.63 Mb Chr 1: 163.94 – 163.98 Mb PubMed search [3] [4]
Wikidata
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P-selectin is a type-1 transmembrane protein that in humans is encoded by the SELP gene.^[5]

P-selectin functions as a cell adhesion molecule (CAM) on the surfaces of activated endothelial cells, which line the inner surface of blood vessels, and activated platelets. In unactivated endothelial cells, it is stored in granules called Weibel-Palade bodies. In unactivated platelets P-selectin is stored in α-granules.

Other names for P-selectin include CD62P, Granule Membrane Protein 140 (GMP-140), and Platelet Activation-Dependent Granule to External Membrane Protein (PADGEM). It was first identified in endothelial cells in 1989.^[6]