PARD3

PARD3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2KOM
Identifiers
Aliases	PARD3, ASIP, Baz, PAR3, PAR3alpha, PARD-3, PARD3A, PPP1R118, SE2-5L16, SE2-5LT1, SE2-5T2, par-3 family cell polarity regulator
External IDs	OMIM: 606745; MGI: 2135608; HomoloGene: 10489; GeneCards: PARD3; OMA:PARD3 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	34,815,325 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	128,338,767 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; skin of abdomen; ; skin of leg; ; buccal mucosa cell; ; gingival epithelium; ; nipple; ; mucosa of pharynx; ; Achilles tendon; ; internal globus pallidus; ; gastric mucosa;
	Top expressed in
	esophagus; ; lip; ; tail of embryo; ; secondary oocyte; ; conjunctival fornix; ; transitional epithelium of urinary bladder; ; genital tubercle; ; ventricular zone; ; hand; ; cornea;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	phosphatidylinositol-3-phosphate binding; protein binding; phosphatidylinositol-4,5-bisphosphate binding; protein phosphatase binding; phosphatidylinositol-3,4,5-trisphosphate binding; lipid binding; identical protein binding; phosphatidylinositol binding;
Cellular component	cytoplasm; cytosol; membrane; cell-cell junction; bicellular tight junction; plasma membrane; axonal growth cone; internode region of axon; cell junction; neuronal cell body; cell cortex; cytoskeleton; endomembrane system; adherens junction; protein-containing complex; apical plasma membrane; apical junction complex;
Biological process	establishment of epithelial cell polarity; cell differentiation; axonogenesis; protein targeting to membrane; negative regulation of peptidyl-threonine phosphorylation; myelination in peripheral nervous system; cell division; establishment or maintenance of cell polarity; positive regulation of myelination; regulation of cellular localization; protein kinase C-activating G protein-coupled receptor signaling pathway; asymmetric cell division; bicellular tight junction assembly; cell cycle; transforming growth factor beta receptor signaling pathway; protein-containing complex assembly; microtubule cytoskeleton organization; cell adhesion; protein localization; establishment of cell polarity; establishment or maintenance of epithelial cell apical/basal polarity; establishment of centrosome localization;
	Sources:Amigo / QuickGO
Orthologs
	56288
	93742
	ENSG00000148498
	ENSMUSG00000025812
	Q8TEW0
	Q99NH2
NM_001184785; NM_001184786; NM_001184787; NM_001184788; NM_001184789;
	NM_001184790; NM_001184791; NM_001184792; NM_001184793; NM_001184794; NM_019619
NM_001013580; NM_001013581; NM_001122850; NM_033620; NM_001309391;
	NM_001309392; NM_001363431; NM_001363432
NP_001171714; NP_001171715; NP_001171716; NP_001171717; NP_001171718;
	NP_001171719; NP_001171720; NP_001171721; NP_001171722; NP_001171723; NP_062565
NP_001013598; NP_001013599; NP_001116322; NP_001296320; NP_001296321;
	NP_296369; NP_001350360; NP_001350361
	Wikidata
View/Edit Human	View/Edit Mouse

Partitioning defective 3 homolog is a protein that in humans is encoded by the PARD3 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000148498 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025812 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Joberty G, Petersen C, Gao L, Macara IG (Oct 2000). "The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42". Nat Cell Biol. 2 (8): 531–9. doi:10.1038/35019573. PMID 10934474. S2CID 27139234.
^ "Entrez Gene: PARD3 par-3 partitioning defective 3 homolog (C. elegans)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000148498 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025812 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10934474-5] Joberty G, Petersen C, Gao L, Macara IG (Oct 2000). "The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42". Nat Cell Biol. 2 (8): 531–9. doi:10.1038/35019573. PMID 10934474. S2CID 27139234.

[entrez-6] "Entrez Gene: PARD3 par-3 partitioning defective 3 homolog (C. elegans)".

[1]

[2]

[3]

[4]

[5]

[6]