PDCD1LG2

PDCD1LG2
Identifiers
Aliases	PDCD1LG2, B7DC, Btdc, CD273, PD-L2, PDCD1L2, PDL2, bA574F11.2, programmed cell death 1 ligand 2
External IDs	OMIM: 605723; MGI: 1930125; HomoloGene: 10973; GeneCards: PDCD1LG2; OMA:PDCD1LG2 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	5,571,282 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	29,448,561 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; testicle; ; Achilles tendon; ; appendix; ; lymph node; ; spleen; ; gallbladder; ; smooth muscle tissue; ; upper lobe of left lung; ; right lung;
	Top expressed in
	gastrula; ; embryo; ; submandibular gland; ; thymus; ; mesenteric lymph nodes; ; lumbar spinal ganglion; ; tibiofemoral joint; ; spleen; ; skin of abdomen; ; blood;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	molecular function; protein binding;
Cellular component	integral component of membrane; extracellular region; endomembrane system; membrane; plasma membrane; external side of plasma membrane; cell surface;
Biological process	negative regulation of activated T cell proliferation; T cell costimulation; negative regulation of interleukin-10 production; negative regulation of T cell proliferation; negative regulation of interferon-gamma production; immune response; positive regulation of T cell proliferation; signal transduction; cell surface receptor signaling pathway; cellular response to lipopolysaccharide; adaptive immune response; immune system process;
	Sources:Amigo / QuickGO
Orthologs
	80380
	58205
	ENSG00000197646
	ENSMUSG00000016498
	Q9BQ51
	Q9WUL5
	NM_025239
	NM_021396
	NP_079515
	NP_067371
	Wikidata
View/Edit Human	View/Edit Mouse

Programmed cell death 1 ligand 2 (also known as PD-L2, B7-DC) is a protein that in humans is encoded by the PDCD1LG2 gene.^[5]^[6] PDCD1LG2 has also been designated as CD273 (cluster of differentiation 273). PDCD1LG2 is an immune checkpoint receptor ligand which plays a role in negative regulation of the adaptive immune response.^[5]^[7] PD-L2 is one of two known ligands for Programmed cell death protein 1 (PD-1).^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000197646 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000016498 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b ^c Latchman Y, Wood CR, Chernova T, Chaudhary D, Borde M, Chernova I, et al. (March 2001). "PD-L2 is a second ligand for PD-1 and inhibits T cell activation". Nature Immunology. 2 (3): 261–8. doi:10.1038/85330. PMID 11224527. S2CID 27659586.
^ "Entrez Gene: PDCD1LG2 programmed cell death 1 ligand 2".
^ McDermott DF, Atkins MB (October 2013). "PD-1 as a potential target in cancer therapy". Cancer Medicine. 2 (5): 662–73. doi:10.1002/cam4.106. PMC 3892798. PMID 24403232.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000197646 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000016498 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11224527-5] Latchman Y, Wood CR, Chernova T, Chaudhary D, Borde M, Chernova I, et al. (March 2001). "PD-L2 is a second ligand for PD-1 and inhibits T cell activation". Nature Immunology. 2 (3): 261–8. doi:10.1038/85330. PMID 11224527. S2CID 27659586.

[entrez-6] "Entrez Gene: PDCD1LG2 programmed cell death 1 ligand 2".

[7] McDermott DF, Atkins MB (October 2013). "PD-1 as a potential target in cancer therapy". Cancer Medicine. 2 (5): 662–73. doi:10.1002/cam4.106. PMC 3892798. PMID 24403232.

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