PDGFRB

PDGFRB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1GQ5, 1H9O, 1SHA, 2L6W, 2PLD, 2PLE, 3MJG
Identifiers
Aliases	PDGFRB, CD140B, IBGC4, IMF1, JTK12, PDGFR, PDGFR-1, PDGFR1, KOGS, PENTT, platelet derived growth factor receptor beta
External IDs	OMIM: 173410; MGI: 97531; HomoloGene: 1960; GeneCards: PDGFRB; OMA:PDGFRB - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q32 Start 150,113,839 bp[1] End 150,155,872 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18 E1|18 34.41 cM Start 61,178,222 bp[2] End 61,218,133 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium right coronary artery canal of the cervix tibial arteries gallbladder Descending thoracic aorta right ovary Achilles tendon right lung left coronary artery Top expressed in external carotid artery internal carotid artery tunica media of zone of aorta calvaria epithelium of lens left lung lobe vas deferens body of femur dermis ascending aorta More reference expression data BioGPS More reference expression data
Gene ontology Molecular function vascular endothelial growth factor binding kinase activity platelet-derived growth factor-activated receptor activity transmembrane receptor protein tyrosine kinase activity signaling receptor binding ATP binding protein kinase activity platelet-derived growth factor binding platelet activating factor receptor activity transferase activity platelet-derived growth factor receptor binding protein binding protein tyrosine kinase activity protein kinase binding platelet-derived growth factor beta-receptor activity nucleotide binding phosphatidylinositol 3-kinase binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity enzyme binding Cellular component cytoplasm membrane focal adhesion nucleus apical plasma membrane lysosome extracellular exosome integral component of membrane plasma membrane lysosomal lumen intrinsic component of plasma membrane cytoplasmic vesicle cell surface Golgi apparatus integral component of plasma membrane intracellular membrane-bounded organelle receptor complex Biological process positive regulation of MAP kinase activity positive regulation of phospholipase C activity cell migration involved in vasculogenesis cardiac myofibril assembly positive regulation of smooth muscle cell migration protein phosphorylation response to lipid positive regulation of phosphoprotein phosphatase activity positive regulation of reactive oxygen species metabolic process metanephric glomerular mesangial cell proliferation involved in metanephros development positive regulation of ERK1 and ERK2 cascade cell chemotaxis inner ear development metanephric S-shaped body morphogenesis positive regulation of mitotic nuclear division platelet-derived growth factor receptor-beta signaling pathway positive regulation of collagen biosynthetic process phosphatidylinositol metabolic process transmembrane receptor protein tyrosine kinase signaling pathway cell migration involved in coronary angiogenesis metanephric comma-shaped body morphogenesis positive regulation of chemotaxis positive regulation of DNA biosynthetic process protein autophosphorylation platelet-derived growth factor receptor signaling pathway response to toxic substance positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway regulation of actin cytoskeleton organization response to retinoic acid phosphorylation response to hyperoxia retina vasculature development in camera-type eye metanephric glomerulus morphogenesis metanephric mesenchymal cell migration wound healing cellular response to platelet-derived growth factor stimulus negative regulation of apoptotic process response to fluid shear stress response to estrogen chemotaxis metanephric mesenchyme development response to hydrogen peroxide positive regulation of smooth muscle cell proliferation response to estradiol intracellular signal transduction response to organic cyclic compound smooth muscle cell chemotaxis positive regulation of cell migration aorta morphogenesis MAPK cascade positive regulation of phosphatidylinositol 3-kinase activity metanephric glomerular capillary formation multicellular organism development positive regulation of calcium ion import glycosaminoglycan biosynthetic process positive regulation of cell population proliferation positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway positive regulation of phosphatidylinositol 3-kinase signaling peptidyl-tyrosine phosphorylation cell migration signal transduction positive regulation of Rho protein signal transduction G protein-coupled receptor signaling pathway phosphatidylinositol phosphate biosynthetic process positive regulation of hepatic stellate cell activation positive regulation of fibroblast proliferation positive regulation of apoptotic process human ageing male gonad development lung growth negative regulation of platelet-derived growth factor receptor-beta signaling pathway phosphatidylinositol-mediated signaling positive regulation of protein kinase B signaling hematopoietic progenitor cell differentiation positive regulation of MAPK cascade Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5159 18596 Ensembl ENSG00000113721 ENSMUSG00000024620 UniProt P09619 P05622 RefSeq (mRNA) NM_002609 NM_001355016 NM_001355017 NM_001146268 NM_008809 RefSeq (protein) NP_002600 NP_001341945 NP_001341946 NP_001139740 NP_032835 Location (UCSC) Chr 5: 150.11 – 150.16 Mb Chr 18: 61.18 – 61.22 Mb PubMed search [3] [4]
Wikidata
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Platelet-derived growth factor receptor beta is a protein that in humans is encoded by the PDGFRB gene. Mutations in PDGFRB are mainly associated with the clonal eosinophilia class of malignancies.