PLA2R1

PLA2R1
Identifiers
Aliases	PLA2R1, CLEC13C, PLA2-R, PLA2G1R, PLA2IR, PLA2R, phospholipase A2 receptor 1
External IDs	OMIM: 604939; MGI: 102468; HomoloGene: 32016; GeneCards: PLA2R1; OMA:PLA2R1 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	160,062,615 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	60,383,652 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; left lobe of thyroid gland; ; Achilles tendon; ; right lobe of thyroid gland; ; right coronary artery; ; popliteal artery; ; tibial arteries; ; olfactory zone of nasal mucosa; ; Descending thoracic aorta; ; skin of leg;
	Top expressed in
	neural layer of retina; ; transitional epithelium of urinary bladder; ; molar; ; olfactory epithelium; ; retinal pigment epithelium; ; decidua; ; pineal gland; ; belly cord; ; gastrula; ; uterus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phospholipase binding; carbohydrate binding; transmembrane signaling receptor activity; signaling receptor activity;
Cellular component	integral component of membrane; extracellular region; cell surface; receptor complex; plasma membrane; membrane; integral component of plasma membrane;
Biological process	cytokine production; positive regulation of DNA damage response, signal transduction by p53 class mediator; endocytosis; positive regulation of arachidonic acid secretion; receptor-mediated endocytosis; oxidative stress-induced premature senescence; reactive oxygen species metabolic process; replicative senescence; signal transduction; negative regulation of phospholipase A2 activity; negative regulation of arachidonic acid secretion;
	Sources:Amigo / QuickGO
Orthologs
	22925
	18779
	ENSG00000153246
	ENSMUSG00000054580
	Q13018
	Q62028
	NM_001007267; NM_001195641; NM_007366
	NM_008867
	NP_001007268; NP_001182570; NP_031392
	NP_032893
	Wikidata
View/Edit Human	View/Edit Mouse

Secretory phospholipase A2 receptor is a protein that in humans is encoded by the PLA2R1 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000153246 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000054580 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ancian P, Lambeau G, Mattéi MG, Lazdunski M (Apr 1995). "The human 180-kDa receptor for secretory phospholipases A2. Molecular cloning, identification of a secreted soluble form, expression, and chromosomal localization". The Journal of Biological Chemistry. 270 (15): 8963–70. doi:10.1074/jbc.270.15.8963. PMID 7721806.
^ Higashino K, Ishizaki J, Kishino J, Ohara O, Arita H (Oct 1994). "Structural comparison of phospholipase-A2-binding regions in phospholipase-A2 receptors from various mammals". European Journal of Biochemistry. 225 (1): 375–82. doi:10.1111/j.1432-1033.1994.00375.x. PMID 7925459.
^ "Entrez Gene: PLA2R1 phospholipase A2 receptor 1, 180kDa".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000153246 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000054580 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7721806-5] Ancian P, Lambeau G, Mattéi MG, Lazdunski M (Apr 1995). "The human 180-kDa receptor for secretory phospholipases A2. Molecular cloning, identification of a secreted soluble form, expression, and chromosomal localization". The Journal of Biological Chemistry. 270 (15): 8963–70. doi:10.1074/jbc.270.15.8963. PMID 7721806.

[pmid7925459-6] Higashino K, Ishizaki J, Kishino J, Ohara O, Arita H (Oct 1994). "Structural comparison of phospholipase-A2-binding regions in phospholipase-A2 receptors from various mammals". European Journal of Biochemistry. 225 (1): 375–82. doi:10.1111/j.1432-1033.1994.00375.x. PMID 7925459.

[entrez-7] "Entrez Gene: PLA2R1 phospholipase A2 receptor 1, 180kDa".

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