PTPN11

PTPN11
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2SHP, 3B7O, 3MOW, 3O5X, 3TKZ, 3TL0, 4DGP, 4DGX, 4GWF, 4H1O, 4JE4, 4JEG, 3ZM0, 3ZM1, 3ZM2, 3ZM3, 4H34, 4JMG, 4NWF, 4NWG, 4OHD, 4OHE, 4OHH, 4OHI, 4OHL, 4PVG, 4RDD, 4QSY, 5DF6, 5IBS, 5EHP, 5EHR, 5I6V, 5IBM
Identifiers
Aliases	PTPN11, BPTP3, CFC, JMML, METCDS, NS1, PTP-1D, PTP2C, SH-PTP2, SH-PTP3, SHP2, protein tyrosine phosphatase, non-receptor type 11, protein tyrosine phosphatase non-receptor type 11
External IDs	OMIM: 176876; MGI: 99511; HomoloGene: 2122; GeneCards: PTPN11; OMA:PTPN11 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q24.13 Start 112,418,351 bp[1] End 112,509,918 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 F Start 121,268,596 bp[2] End 121,329,460 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in internal globus pallidus dorsal motor nucleus of vagus nerve Brodmann area 23 visceral pleura parietal pleura subthalamic nucleus pars reticulata inferior olivary nucleus Epithelium of choroid plexus external globus pallidus Top expressed in renal corpuscle Epithelium of choroid plexus utricle medullary collecting duct retinal pigment epithelium substantia nigra ciliary body iris endocardial cushion primitive streak More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phospholipase binding phosphoprotein phosphatase activity insulin receptor binding phosphatase activity receptor tyrosine kinase binding peptide hormone receptor binding protein binding non-membrane spanning protein tyrosine phosphatase activity hydrolase activity phosphatidylinositol-4,5-bisphosphate 3-kinase activity 1-phosphatidylinositol-3-kinase activity cell adhesion molecule binding protein tyrosine phosphatase activity phosphotyrosine residue binding protein domain specific binding D1 dopamine receptor binding insulin receptor substrate binding protein tyrosine kinase binding protein kinase binding Cellular component cytoplasm cytosol mitochondrion nucleus nucleoplasm protein-containing complex Biological process dephosphorylation megakaryocyte development positive regulation of signal transduction negative regulation of insulin secretion regulation of cell adhesion mediated by integrin atrioventricular canal development intestinal epithelial cell migration organ growth epidermal growth factor receptor signaling pathway negative regulation of growth hormone secretion axonogenesis glucose homeostasis regulation of protein export from nucleus multicellular organism growth regulation of multicellular organism growth lipid metabolism ephrin receptor signaling pathway abortive mitotic cell cycle DNA damage checkpoint signaling protein dephosphorylation T cell costimulation platelet formation microvillus organization positive regulation of mitotic cell cycle genitalia development platelet activation fibroblast growth factor receptor signaling pathway heart development brain development regulation of type I interferon-mediated signaling pathway hormone-mediated signaling pathway integrin-mediated signaling pathway Bergmann glial cell differentiation homeostasis of number of cells within a tissue inner ear development platelet-derived growth factor receptor signaling pathway negative regulation of cortisol secretion peptidyl-tyrosine dephosphorylation ERBB signaling pathway negative regulation of hormone secretion triglyceride metabolic process hormone metabolic process positive regulation of hormone secretion negative regulation of cell adhesion mediated by integrin regulation of protein-containing complex assembly face morphogenesis cerebellar cortex formation leukocyte migration multicellular organismal reproductive process phosphatidylinositol phosphate biosynthetic process neurotrophin TRK receptor signaling pathway phosphatidylinositol-3-phosphate biosynthetic process axon guidance positive regulation of ERK1 and ERK2 cascade cellular response to epidermal growth factor stimulus positive regulation of protein kinase B signaling cytokine-mediated signaling pathway interleukin-6-mediated signaling pathway cellular response to cytokine stimulus cellular response to mechanical stimulus positive regulation of interferon-beta production positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production positive regulation of glucose import positive regulation of insulin receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5781 19247 Ensembl ENSG00000179295 ENSMUSG00000043733 UniProt Q06124 P35235 RefSeq (mRNA) NM_002834 NM_080601 NM_001330437 NM_001374625 NM_018508 NM_001109992 NM_011202 RefSeq (protein) NP_001317366 NP_002825 NP_542168 NP_001361554 NP_001103462 NP_035332 Location (UCSC) Chr 12: 112.42 – 112.51 Mb Chr 5: 121.27 – 121.33 Mb PubMed search [3] [4]
Wikidata
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Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) also known as protein-tyrosine phosphatase 1D (PTP-1D), Src homology region 2 domain-containing phosphatase-2 (SHP-2), or protein-tyrosine phosphatase 2C (PTP-2C) is an enzyme that in humans is encoded by the PTPN11 gene. PTPN11 is a protein tyrosine phosphatase (PTP) Shp2.^[5][6]

PTPN11 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia.^[7]