Pancreatic stellate cell

Pancreatic stellate cell
Pancreatic stellate cell
Details
Location	Pancreas
Identifiers
MeSH	D058954
	Anatomical terms of microanatomy

Pancreatic stellate cells (PaSCs) are classified as myofibroblast-like cells that are located in exocrine regions of the pancreas.^[1] PaSCs are mediated by paracrine and autocrine stimuli and share similarities with the hepatic stellate cell.^[1] Pancreatic stellate cell activation and expression of matrix molecules constitute the complex process that induces pancreatic fibrosis.^[2] Synthesis, deposition, maturation and remodelling of the fibrous connective tissue can be protective, however when persistent it impedes regular pancreatic function.^[2]

^ ^a ^b Omary MB, Lugea A, Lowe AW, Pandol SJ (January 2007). "The pancreatic stellate cell: a star on the rise in pancreatic diseases". J. Clin. Invest. 117 (1): 50–9. doi:10.1172/JCI30082. ISSN 0021-9738. PMC 1716214. PMID 17200706.
^ ^a ^b Charo C, Holla V, Arumugam T, Hwang R, Yang P, Dubois RN, Menter DG, Logsdon CD, Ramachandran V (April 2013). "Prostaglandin E2 regulates pancreatic stellate cell activity via the EP4 receptor". Pancreas. 42 (3): 467–74. doi:10.1097/MPA.0b013e318264d0f8. ISSN 0885-3177. PMC 3600062. PMID 23090667.

[pmid17200706-1] Omary MB, Lugea A, Lowe AW, Pandol SJ (January 2007). "The pancreatic stellate cell: a star on the rise in pancreatic diseases". J. Clin. Invest. 117 (1): 50–9. doi:10.1172/JCI30082. ISSN 0021-9738. PMC 1716214. PMID 17200706.

[pmid23090667-2] Charo C, Holla V, Arumugam T, Hwang R, Yang P, Dubois RN, Menter DG, Logsdon CD, Ramachandran V (April 2013). "Prostaglandin E2 regulates pancreatic stellate cell activity via the EP4 receptor". Pancreas. 42 (3): 467–74. doi:10.1097/MPA.0b013e318264d0f8. ISSN 0885-3177. PMC 3600062. PMID 23090667.

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