| Paralytic | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | para | ||||||
| Alt. symbols | bss, sbl, olfD, DmNav, DmNav1, DmNav | ||||||
| NCBI gene | 32619 | ||||||
| UniProt | P35500 | ||||||
| Other data | |||||||
| Locus | Chr. X 16,455,230 - 16,533,368 | ||||||
| |||||||
Paralytic is a gene in the fruit fly, Drosophila melanogaster, which encodes a voltage gated sodium channel within D. melanogaster neurons.[1] This gene is essential for locomotive activity in the fly.[1] There are 9 different para alleles, composed of a minimum of 26 exons within over 78kb[2] of genomic DNA.[3] The para gene undergoes alternative splicing to produce subtypes of the channel protein.[3] Flies with mutant forms of paralytic are used in fly models of seizures, since seizures can be easily induced in these flies.[4]
- ^ a b "Dmel\para". FlyBase. Retrieved 28 March 2017.
- ^ "D. melanogaster chrX:16,455,230-16,533,368 - UCSC Genome Browser v357". genome.ucsc.edu. Retrieved 2017-11-22.
- ^ a b Loughney K, Kreber R, Ganetzky B (September 1989). "Molecular analysis of the para locus, a sodium channel gene in Drosophila". Cell. 58 (6): 1143–54. doi:10.1016/0092-8674(89)90512-6. PMID 2550145. S2CID 8375638.
- ^ Parker L, Padilla M, Du Y, Dong K, Tanouye MA (February 2011). "Drosophila as a model for epilepsy: bss is a gain-of-function mutation in the para sodium channel gene that leads to seizures". Genetics. 187 (2): 523–34. doi:10.1534/genetics.110.123299. PMC 3030494. PMID 21115970.
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