Parathyroid hormone-related protein

PTHLH
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3H3G, 1BZG, 1M5N, 3FFD
Identifiers
Aliases	PTHLH, BDE2, HHM, PLP, PTHR, PTHRP, parathyroid hormone-like hormone, parathyroid hormone like hormone
External IDs	OMIM: 168470; MGI: 97800; HomoloGene: 2113; GeneCards: PTHLH; OMA:PTHLH - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p11.22 Start 27,958,084 bp[1] End 27,972,733 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 G3|6 78.19 cM Start 147,153,599 bp[2] End 147,165,681 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in periodontal fiber gonad stromal cell of endometrium ectocervix canal of the cervix endothelial cell vagina Descending thoracic aorta ascending aorta gallbladder Top expressed in lip choroid plexus of fourth ventricle semi-lunar valve ankle hair follicle epithelium of stomach corneal stroma aortic valve extraocular muscle Epithelium of choroid plexus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptide hormone receptor binding hormone activity protein binding Cellular component extracellular region nucleus Golgi apparatus nucleoplasm extracellular space cytoplasm cytosol Biological process regulation of gene expression skeletal system development osteoblast development cell-cell signaling female pregnancy negative regulation of chondrocyte differentiation adenylate cyclase-activating G protein-coupled receptor signaling pathway cAMP metabolic process positive regulation of cell population proliferation negative regulation of cell population proliferation epidermis development regulation of signaling receptor activity G protein-coupled receptor signaling pathway bone mineralization negative regulation of chondrocyte development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5744 19227 Ensembl ENSG00000087494 ENSMUSG00000048776 UniProt P12272 P22858 RefSeq (mRNA) NM_002820 NM_198964 NM_198965 NM_198966 NM_008970 RefSeq (protein) NP_002811 NP_945315 NP_945316 NP_945317 n/a Location (UCSC) Chr 12: 27.96 – 27.97 Mb Chr 6: 147.15 – 147.17 Mb PubMed search [3] [4]
Wikidata
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Parathyroid hormone-related protein (PTHrP) is a proteinaceous hormone and a member of the parathyroid hormone family secreted by mesenchymal stem cells. It is occasionally secreted by cancer cells (for example, breast cancer, certain types of lung cancer including squamous-cell lung carcinoma). However, it also has normal functions in bone, teeth, vascular tissues and other tissues.