Parathyroid hormone 1 receptor

PTH1R
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1BL1, 3C4M, 3H3G, 3L2J, 4Z8J
Identifiers
Aliases	PTH1R, PFE, PTHR, PTHR1, Parathyroid hormone 1 receptor, EKNS
External IDs	OMIM: 168468; MGI: 97801; HomoloGene: 267; GeneCards: PTH1R; OMA:PTH1R - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p21.31 Start 46,877,721 bp[1] End 46,903,799 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 F2|9 60.56 cM Start 110,722,085 bp[2] End 110,747,145 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibia human kidney right adrenal cortex right lobe of liver periodontal fiber metanephric glomerulus left adrenal cortex right lung kidney tubule apex of heart Top expressed in right kidney proximal tubule human kidney body of femur calvaria clavicle dermis internal carotid artery membranous bone ankle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity parathyroid hormone receptor activity signal transducer activity protein self-association peptide hormone binding protein binding transmembrane signaling receptor activity protein homodimerization activity G protein-coupled peptide receptor activity Cellular component cytoplasm integral component of membrane membrane receptor complex plasma membrane intracellular anatomical structure brush border membrane basolateral plasma membrane apical plasma membrane nucleus integral component of plasma membrane Biological process skeletal system development G protein-coupled receptor signaling pathway bone mineralization chondrocyte differentiation ossification positive regulation of inositol phosphate biosynthetic process adenylate cyclase-modulating G protein-coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger human ageing cellular calcium ion homeostasis cell maturation bone resorption phospholipase C-activating G protein-coupled receptor signaling pathway cell surface receptor signaling pathway positive regulation of cell population proliferation osteoblast development signal transduction negative regulation of cell population proliferation adenylate cyclase-activating G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5745 19228 Ensembl ENSG00000160801 ENSMUSG00000032492 UniProt Q03431 P41593 RefSeq (mRNA) NM_000316 NM_001184744 NM_001083935 NM_001083936 NM_011199 RefSeq (protein) NP_000307 NP_001171673 NP_001077404 NP_001077405 NP_035329 Location (UCSC) Chr 3: 46.88 – 46.9 Mb Chr 9: 110.72 – 110.75 Mb PubMed search [3] [4]
Wikidata
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Parathyroid hormone/parathyroid hormone-related peptide receptor, also known as parathyroid hormone 1 receptor (PTH1R), is a protein that in humans is encoded by the PTH1R gene. PTH1R functions as a receptor for parathyroid hormone (PTH) and for parathyroid hormone-related protein (PTHrP), also called parathyroid hormone-like hormone (PTHLH).