Peroxisome proliferator-activated receptor alpha

PPARA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1I7G, 1K7L, 1KKQ, 2NPA, 2P54, 2REW, 2ZNN, 3ET1, 3FEI, 3G8I, 3KDT, 3KDU, 3SP6, 3VI8, 4BCR, 4CI4, 5AZT
Identifiers
Aliases	PPARA, NR1C1, PPAR, PPARalpha, hPPAR, peroxisome proliferator activated receptor alpha, PPAR-alpha
External IDs	MGI: 104740; HomoloGene: 21047; GeneCards: PPARA; OMA:PPARA - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.31 Start 46,150,521 bp[1] End 46,243,755 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 E2|15 40.42 cM Start 85,619,184 bp[2] End 85,687,020 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in renal medulla jejunal mucosa biceps brachii Skeletal muscle tissue of biceps brachii right lobe of liver retinal pigment epithelium muscle of thigh right ventricle body of tongue mucosa of sigmoid colon Top expressed in left lobe of liver right kidney intercostal muscle brown adipose tissue digastric muscle human kidney sternocleidomastoid muscle thoracic diaphragm soleus muscle transitional epithelium of urinary bladder More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding sequence-specific DNA binding protein domain specific binding DNA-binding transcription factor activity zinc ion binding DNA-binding transcription activator activity, RNA polymerase II-specific metal ion binding RNA polymerase II cis-regulatory region sequence-specific DNA binding steroid hormone receptor activity DNA-binding transcription repressor activity, RNA polymerase II-specific nuclear receptor activity protein binding ubiquitin conjugating enzyme binding lipid binding transcription factor binding DNA-binding transcription factor activity, RNA polymerase II-specific signaling receptor activity protein-containing complex binding transcription coactivator binding phosphatase binding NFAT protein binding MDM2/MDM4 family protein binding transcription cis-regulatory region binding RNA polymerase II transcription regulatory region sequence-specific DNA binding fatty acid binding nuclear receptor coactivator activity Cellular component nucleus nucleoplasm RNA polymerase II transcription regulator complex Biological process lipoprotein metabolic process negative regulation of pri-miRNA transcription by RNA polymerase II positive regulation of fatty acid beta-oxidation negative regulation of glycolytic process response to hypoxia regulation of transcription, DNA-templated negative regulation of blood pressure lipid metabolism rhythmic process wound healing negative regulation of leukocyte cell-cell adhesion negative regulation of transcription by RNA polymerase II fatty acid transport negative regulation of protein binding negative regulation of appetite circadian regulation of gene expression transcription, DNA-templated fatty acid metabolic process behavioral response to nicotine positive regulation of transcription, DNA-templated negative regulation of cholesterol storage response to insulin heart development intracellular receptor signaling pathway negative regulation of transcription regulatory region DNA binding negative regulation of sequestering of triglyceride regulation of circadian rhythm regulation of fatty acid metabolic process epidermis development regulation of gene expression enamel mineralization positive regulation of gluconeogenesis transcription initiation from RNA polymerase II promoter negative regulation of inflammatory response negative regulation of macrophage derived foam cell differentiation positive regulation of transcription by RNA polymerase II steroid hormone mediated signaling pathway negative regulation of neuron death positive regulation of fatty acid oxidation regulation of lipid metabolic process signal transduction multicellular organism development hormone-mediated signaling pathway cell differentiation response to lipid negative regulation of transcription, DNA-templated negative regulation of cell growth involved in cardiac muscle cell development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5465 19013 Ensembl ENSG00000186951 ENSMUSG00000022383 UniProt Q07869 Q86SF0 P23204 RefSeq (mRNA) NM_001001928 NM_001001929 NM_001001930 NM_005036 NM_032644 NM_001362872 NM_001362873 NM_001393941 NM_001393942 NM_001393943 NM_001393944 NM_001393945 NM_001393946 NM_001393947 NM_001113418 NM_011144 RefSeq (protein) NP_001001928 NP_005027 NP_001349801 NP_001349802 NP_001106889 NP_035274 Location (UCSC) Chr 22: 46.15 – 46.24 Mb Chr 15: 85.62 – 85.69 Mb PubMed search [3] [4]
Wikidata
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Peroxisome proliferator-activated receptor alpha (PPAR-α), also known as NR1C1 (nuclear receptor subfamily 1, group C, member 1), is a nuclear receptor protein functioning as a transcription factor that in humans is encoded by the PPARA gene.^[5] Together with peroxisome proliferator-activated receptor delta and peroxisome proliferator-activated receptor gamma, PPAR-alpha is part of the subfamily of peroxisome proliferator-activated receptors. It was the first member of the PPAR family to be cloned in 1990 by Stephen Green and has been identified as the nuclear receptor for a diverse class of rodent hepatocarcinogens that causes proliferation of peroxisomes.^[6]