Phosphatidylinositol-4,5-bisphosphate 3-kinase | |||||||||
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![]() PIK-93 inhibitor (yellow) bound to the PI3K 110 gamma subunit .[1] | |||||||||
Identifiers | |||||||||
Symbol | PI3K | ||||||||
Pfam | PF00454 | ||||||||
InterPro | IPR000403 | ||||||||
SMART | SM00146 | ||||||||
PROSITE | PDOC00710 | ||||||||
SCOP2 | 3gmm / SCOPe / SUPFAM | ||||||||
OPM superfamily | 265 | ||||||||
OPM protein | 3ml9 | ||||||||
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Phosphoinositide 3-kinase | |||||||||
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Identifiers | |||||||||
EC no. | 2.7.1.137 | ||||||||
CAS no. | 115926-52-8 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Phosphoinositide 3-kinases (PI3Ks), also called phosphatidylinositol 3-kinases, are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer.
PI3Ks are a family of related intracellular signal transducer enzymes capable of phosphorylating the 3 position hydroxyl group of the inositol ring of phosphatidylinositol (PtdIns).[2] The pathway, with oncogene PIK3CA and tumor suppressor gene PTEN, is implicated in the sensitivity of cancer tumors to insulin and IGF1, and in calorie restriction.[3][4]
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