Picrotoxin

Picrotoxin

Picrotoxinin (left) and picrotin (right)
Clinical data
ATC code	none
Identifiers
CAS Number	124-87-8 Y
PubChem CID	5360688
IUPHAR/BPS	4051
DrugBank	DB00466 Y
ChemSpider	16736444 Y
UNII	ZLT174DL7U
KEGG	C09529 N
ChEBI	CHEBI:134126 N
ChEMBL	ChEMBL506977 Y
CompTox Dashboard (EPA)	DTXSID7045605
ECHA InfoCard	100.004.288
Chemical and physical data
3D model (JSmol)	Interactive image
SMILES CC(=C)[C@H]1[C@@H]2C(=O)O[C@H]1[C@H]3OC(=O)[C@@]54O[C@@H]5C[C@]2(O)[C@@]34C.CC(C)(O)[C@H]5[C@@H]1C(=O)O[C@H]5[C@H]2OC(=O)[C@@]43O[C@@H]4C[C@]1(O)[C@@]23C
InChI InChI=1S/C15H18O7.C15H16O6/c1-12(2,18)6-7-10(16)20-8(6)9-13(3)14(7,19)4-5-15(13,22-5)11(17)21-9;1-5(2)7-8-11(16)19-9(7)10-13(3)14(8,18)4-6-15(13,21-6)12(17)20-10/h5-9,18-19H,4H2,1-3H3;6-10,18H,1,4H2,2-3H3/t5-,6+,7-,8-,9-,13-,14-,15+;6-,7+,8-,9-,10-,13-,14-,15+/m11/s1 Y Key:VJKUPQSHOVKBCO-AHMKVGDJSA-N Y
NY (what is this?)  (verify)

Picrotoxin, also known as cocculin, is a poisonous crystalline plant compound. It was first isolated by the French pharmacist and chemist Pierre François Guillaume Boullay (1777–1869) in 1812.^[1] The name "picrotoxin" is a combination of the Greek words "picros" (bitter) and "toxicon" (poison).^[2] A mixture of two different compounds, picrotoxin occurs naturally in the fruit of the Anamirta cocculus plant, although it can also be synthesized chemically.

Due to its interactions with the inhibitory neurotransmitter GABA, picrotoxin acts as a stimulant and convulsant. It mainly impacts the central nervous system, causing seizures and respiratory paralysis in high enough doses.