Platelet-derived growth factor receptor A

PDGFRA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1GQ5
Identifiers
Aliases	PDGFRA, CD140A, PDGFR-2, PDGFR2, RHEGAS9, platelet derived growth factor receptor alpha
External IDs	OMIM: 173490; MGI: 97530; HomoloGene: 31361; GeneCards: PDGFRA; OMA:PDGFRA - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q12 Start 54,229,280 bp[1] End 54,298,245 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 C3.3|5 39.55 cM Start 75,312,953 bp[2] End 75,358,876 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibia decidua synovial joint pericardium lower lobe of lung pylorus stromal cell of endometrium parietal pleura caput epididymis left ovary Top expressed in vas deferens gastrula efferent ductule stroma of kidney Gonadal ridge vestibular sensory epithelium dermis molar epithelium of lens ankle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function vascular endothelial growth factor-activated receptor activity transferase activity protein kinase activity nucleotide binding protein homodimerization activity vascular endothelial growth factor binding platelet-derived growth factor receptor binding kinase activity protein binding transmembrane receptor protein tyrosine kinase activity platelet-derived growth factor alpha-receptor activity protein tyrosine kinase activity ATP binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity protein-containing complex binding platelet-derived growth factor binding Cellular component integral component of membrane membrane intrinsic component of plasma membrane integral component of plasma membrane plasma membrane cell junction nucleus cytoplasm microvillus external side of plasma membrane cell surface Golgi apparatus cilium protein-containing complex cell projection receptor complex Biological process embryonic skeletal system morphogenesis regulation of actin cytoskeleton reorganization regulation of chemotaxis phosphorylation positive regulation of phospholipase C activity transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of cell migration positive regulation of fibroblast proliferation positive regulation of cytosolic calcium ion concentration cell activation MAPK cascade positive regulation of phosphatidylinositol 3-kinase activity cellular response to reactive oxygen species positive regulation of DNA replication negative regulation of platelet activation protein phosphorylation chemotaxis multicellular organism development positive regulation of cell population proliferation positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway positive regulation of ERK1 and ERK2 cascade positive regulation of phosphatidylinositol 3-kinase signaling platelet-derived growth factor receptor signaling pathway viral process platelet aggregation regulation of mesenchymal stem cell differentiation phosphatidylinositol phosphate biosynthetic process negative regulation of platelet-derived growth factor receptor-beta signaling pathway luteinization in utero embryonic development hematopoietic progenitor cell differentiation estrogen metabolic process female gonad development anatomical structure morphogenesis animal organ morphogenesis cell migration peptidyl-tyrosine phosphorylation signal transduction involved in regulation of gene expression extracellular matrix organization lung development adrenal gland development male genitalia development Leydig cell differentiation platelet-derived growth factor receptor-alpha signaling pathway wound healing odontogenesis of dentin-containing tooth protein autophosphorylation embryonic digestive tract morphogenesis embryonic cranial skeleton morphogenesis skeletal system morphogenesis cardiac myofibril assembly roof of mouth development face morphogenesis cell chemotaxis retina vasculature development in camera-type eye cellular response to amino acid stimulus metanephric glomerular capillary formation phosphatidylinositol-mediated signaling positive regulation of protein kinase B signaling positive regulation of MAPK cascade Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5156 18595 Ensembl ENSG00000134853 ENSMUSG00000029231 UniProt P16234 P26618 RefSeq (mRNA) NM_006206 NM_001347827 NM_001347828 NM_001347829 NM_001347830 NM_001083316 NM_011058 NM_001347718 NM_001347719 RefSeq (protein) NP_001334756 NP_001334757 NP_001334758 NP_001334759 NP_006197 NP_001076785 NP_001334647 NP_001334648 NP_035188 Location (UCSC) Chr 4: 54.23 – 54.3 Mb Chr 5: 75.31 – 75.36 Mb PubMed search [3] [4]
Wikidata
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Platelet-derived growth factor receptor A, also termed CD140a, is a receptor located on the surface of a wide range of cell types. The protein is encoded in the human by the PDGFRA gene. This receptor binds to certain isoforms of platelet-derived growth factors (PDGFs) and thereby becomes active in stimulating cell signaling pathways that elicit responses such as cellular growth and differentiation. The receptor is critical for the embryonic development of certain tissues and organs, and for their maintenance, particularly hematologic tissues, throughout life. Mutations in PDGFRA, are associated with an array of clinically significant neoplasms, notably ones of the clonal hypereosinophilia class of malignancies, as well as gastrointestinal stromal tumors (GISTs).