Platinum-based antineoplastic

Platinum-based antineoplastic drugs (informally called platins) are chemotherapeutic agents used to treat cancer. Their active moieties are coordination complexes of platinum. These drugs are used to treat almost half of people receiving chemotherapy for cancer. In this form of chemotherapy, commonly used drugs include cisplatin, oxaliplatin, and carboplatin, but several have been proposed or are under development.[1] Addition of platinum-based chemotherapy drugs to chemoradiation in women with early cervical cancer seems to improve survival and reduce risk of recurrence.[2]

In total, these drugs can cause a combination of more than 40 specific side effects which include neurotoxicity, which is manifested by peripheral neuropathies including polyneuropathy.[3]

  1. ^ Cite error: The named reference SJL was invoked but never defined (see the help page).
  2. ^ Falcetta, FS; Medeiros, LR; Edelweiss, MI; Pohlmann, PR; Stein, AT; Rosa, DD (22 November 2016). "Adjuvant platinum-based chemotherapy for early stage cervical cancer". The Cochrane Database of Systematic Reviews. 11 (11): CD005342. doi:10.1002/14651858.CD005342.pub4. PMC 4164460. PMID 27873308.
  3. ^ Oun R, Moussa YE, Wheate NJ (2018). "The side effects of platinum-based chemotherapy drugs: a review for chemists". Dalton Transactions. 47 (19): 6645–6653. doi:10.1039/c8dt00838h. PMID 29632935.

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