Polystyrene sulfonate

Polystyrene sulfonate

Clinical data
Trade names	Sodium salt: Kayexalate, Kionex, Resonium A Calcium salt: Calcium Resonium, Sorbisterit, Resikali Potassium and sodium salt: Tolevamer
AHFS/Drugs.com	Monograph
MedlinePlus	a682108
Routes of administration	By mouth, retention enema
ATC code	V03AE01 (WHO)
Legal status
Legal status	In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability	None
Metabolism	None
Excretion	Faeces (100%)
Identifiers
IUPAC name Poly(4-vinylbenzenesulfonic acid)
CAS Number	9002-23-7 Y
PubChem CID	75905
DrugBank	DB01344 Y
ChemSpider	None
UNII	70KO0R01RY
KEGG	DG01160 N
Chemical and physical data
Formula	[C8H7SO3−] n
NY (what is this?)  (verify)

Polystyrene sulfonates are a group of medications used to treat high blood potassium.^[1] Effects generally take hours to days.^[1] They are also used to remove potassium, calcium, and sodium from solutions in technical applications.

Common side effects include loss of appetite, gastrointestinal upset, constipation, and low blood calcium.^[1] These polymers are derived from polystyrene by the addition of sulfonate functional groups.

Sodium polystyrene sulfonate was approved for medical use in the United States in 1958.^[1]

A polystyrene sulfonate was developed in the 2000s to treat Clostridium difficile associated diarrhea under the name Tolevamer,^[2] but it was never marketed.