Potassium-sparing diuretic

Potassium-sparing diuretics or antikaliuretics^[1] refer to drugs that cause diuresis without causing potassium loss in the urine.^[2] They are typically used as an adjunct in management of hypertension, cirrhosis, and congestive heart failure.^[3] The steroidal aldosterone antagonists can also be used for treatment of primary hyperaldosteronism. Spironolactone, a steroidal aldosterone antagonist, is also used in management of female hirsutism and acne from PCOS or other causes.^[4]^[5]

^ Knepper, Mark A.; Kleyman, Thomas; Gamba, Gerardo (2005), "Diuretics: Mechanisms of Action", Hypertension, Elsevier, pp. 638–652, doi:10.1016/b978-0-7216-0258-5.50152-6, ISBN 978-0-7216-0258-5, retrieved 2024-03-24
^ Rose BD (February 1991). "Diuretics". Kidney Int. 39 (2): 336–52. doi:10.1038/ki.1991.43. PMID 2002648.
^ Weber KT, Villarreal D (January 1993). "Aldosterone and antialdosterone therapy in congestive heart failure". The American Journal of Cardiology. 71 (3): A3–A11. doi:10.1016/0002-9149(93)90238-8. PMID 8422002.
^ Martin KA, Anderson RB, et al. (1 April 2018). "Evaluation and Treatment of Hirsutism in Premenopausal Women: An Endocrine Society* Clinical Practice Guideline". The Journal of Clinical Endocrinology & Metabolism. 103 (4): 1233–1257. doi:10.1210/jc.2018-00241. PMID 29522147.
^ Grandhi R, Alikhan A (2017). "Spironolactone for the Treatment of Acne: A 4-Year Retrospective Study". Dermatology. 233 (2–3): 141–144. doi:10.1159/000471799. PMID 28472793.