Proopiomelanocortin

POMC
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2LWC, 5E33, 1PLW, 1PLX
Identifiers
Aliases	POMC, POC, proopiomelanocortin, OBAIRH, LPH, CLIP, ACTH, NPP, MSH
External IDs	OMIM: 176830; MGI: 97742; HomoloGene: 723; GeneCards: POMC; OMA:POMC - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p23.3 Start 25,160,853 bp[1] End 25,168,903 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12 A1.1|12 1.99 cM Start 4,004,951 bp[2] End 4,010,642 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in anterior pituitary right testis left testis gonad body of pancreas right adrenal cortex left adrenal gland apex of heart left adrenal cortex right auricle Top expressed in pituitary gland arcuate nucleus median eminence pars distalis of adenohypophysis pars intermedia ventromedial nucleus suprachiasmatic nucleus trophoblast giant cell seminiferous tubule otic vesicle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function type 3 melanocortin receptor binding hormone activity type 1 melanocortin receptor binding signaling receptor binding G protein-coupled receptor binding type 4 melanocortin receptor binding neuropeptide hormone activity Cellular component cytoplasm peroxisome extracellular region peroxisomal matrix secretory granule lumen extracellular space secretory granule Biological process glucose homeostasis cellular pigmentation cell-cell signaling generation of precursor metabolites and energy regulation of glycogen metabolic process regulation of blood pressure negative regulation of tumor necrosis factor production regulation of appetite signal transduction positive regulation of transcription by RNA polymerase II neuropeptide signaling pathway positive regulation of neutrophil mediated killing of fungus regulation of corticosterone secretion regulation of signaling receptor activity G protein-coupled receptor signaling pathway cytokine-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5443 18976 Ensembl ENSG00000115138 ENSMUSG00000020660 UniProt P01189 P01193 RefSeq (mRNA) NM_000939 NM_001035256 NM_001319204 NM_001319205 NM_008895 NM_001278581 NM_001278582 NM_001278583 NM_001278584 RefSeq (protein) NP_000930 NP_001030333 NP_001306133 NP_001306134 NP_001265510 NP_001265511 NP_001265512 NP_001265513 NP_032921 Location (UCSC) Chr 2: 25.16 – 25.17 Mb Chr 12: 4 – 4.01 Mb PubMed search [3] [4]
Wikidata
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Pro-opiomelanocortin (POMC) is a precursor polypeptide with 241 amino acid residues. POMC is synthesized in corticotrophs of the anterior pituitary from the 267-amino-acid-long polypeptide precursor pre-pro-opiomelanocortin (pre-POMC), by the removal of a 26-amino-acid-long signal peptide sequence during translation.^[5] POMC is part of the central melanocortin system.