Protein targeting

Protein targeting or protein sorting is the biological mechanism by which proteins are transported to their appropriate destinations within or outside the cell.^[1]^[2]^{[note 1]} Proteins can be targeted to the inner space of an organelle, different intracellular membranes, the plasma membrane, or to the exterior of the cell via secretion.^[1]^[2] Information contained in the protein itself directs this delivery process.^[2]^[3] Correct sorting is crucial for the cell; errors or dysfunction in sorting have been linked to multiple diseases.^[2]^[4]^[5]

^ ^a ^b Nelson DL (January 2017). Lehninger principles of biochemistry. Cox, Michael M.,, Lehninger, Albert L. (Seventh ed.). New York, NY. ISBN 978-1-4641-2611-6. OCLC 986827885.{{cite book}}: CS1 maint: location missing publisher (link)
^ ^a ^b ^c ^d Lodish, Berk, Kaiser, Krieger, Bretscher, Ploegh, Martin, Yaffe, Amon (2021). Molecular Cell Biology (9th ed.). New York, NY: W.H. Freeman and Company. ISBN 978-1-319-20852-3.{{cite book}}: CS1 maint: multiple names: authors list (link)
^ Blobel G, Dobberstein B (December 1975). "Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma". The Journal of Cell Biology. 67 (3): 835–51. doi:10.1083/jcb.67.3.835. PMC 2111658. PMID 811671.
^ Schmidt V, Willnow TE (February 2016). "Protein sorting gone wrong--VPS10P domain receptors in cardiovascular and metabolic diseases". Atherosclerosis. 245: 194–9. doi:10.1016/j.atherosclerosis.2015.11.027. PMID 26724530.
^ Guo Y, Sirkis DW, Schekman R (2014-10-11). "Protein sorting at the trans-Golgi network". Annual Review of Cell and Developmental Biology. 30 (1): 169–206. doi:10.1146/annurev-cellbio-100913-013012. PMID 25150009.

Cite error: There are <ref group=note> tags on this page, but the references will not show without a {{reflist|group=note}} template (see the help page).

[Nelson-2017-1] Nelson DL (January 2017). Lehninger principles of biochemistry. Cox, Michael M.,, Lehninger, Albert L. (Seventh ed.). New York, NY. ISBN 978-1-4641-2611-6. OCLC 986827885.{{cite book}}: CS1 maint: location missing publisher (link)

[Lodish,_Berk,_Kaiser,_Krieger,_Bretscher,_Ploegh,_Martin,_Yaffe,_Amon-2021-2] Lodish, Berk, Kaiser, Krieger, Bretscher, Ploegh, Martin, Yaffe, Amon (2021). Molecular Cell Biology (9th ed.). New York, NY: W.H. Freeman and Company. ISBN 978-1-319-20852-3.{{cite book}}: CS1 maint: multiple names: authors list (link)

[Blobel-1975-4] Blobel G, Dobberstein B (December 1975). "Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma". The Journal of Cell Biology. 67 (3): 835–51. doi:10.1083/jcb.67.3.835. PMC 2111658. PMID 811671.

[Protein_sorting_gone_wrong--VPS10P-5] Schmidt V, Willnow TE (February 2016). "Protein sorting gone wrong--VPS10P domain receptors in cardiovascular and metabolic diseases". Atherosclerosis. 245: 194–9. doi:10.1016/j.atherosclerosis.2015.11.027. PMID 26724530.

[6] Guo Y, Sirkis DW, Schekman R (2014-10-11). "Protein sorting at the trans-Golgi network". Annual Review of Cell and Developmental Biology. 30 (1): 169–206. doi:10.1146/annurev-cellbio-100913-013012. PMID 25150009.

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[2]

[note 1]

[3]

[4]

[5]