Resistin

RETN
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1LV6
Identifiers
Aliases	RETN, ADSF, FIZZ3, RETN1, RSTN, XCP1, resistin
External IDs	OMIM: 605565; MGI: 1888506; HomoloGene: 10703; GeneCards: RETN; OMA:RETN - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.2 Start 7,669,049 bp[1] End 7,670,455 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 A1.1|8 1.92 cM Start 3,705,770 bp[2] End 3,710,110 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bone marrow bone marrow cells monocyte trabecular bone granulocyte right lung upper lobe of left lung blood spleen gastric mucosa Top expressed in white adipose tissue subcutaneous adipose tissue tunica adventitia of aorta lactiferous gland intercostal muscle tunica media of zone of aorta mesenteric lymph nodes brown adipose tissue ankle joint skin of abdomen More reference expression data BioGPS More reference expression data
Gene ontology Molecular function hormone activity Cellular component extracellular exosome nucleus extracellular region extracellular space azurophil granule lumen specific granule lumen Biological process positive regulation of smooth muscle cell migration response to insulin positive regulation of progesterone secretion response to mechanical stimulus human ageing positive regulation of collagen metabolic process fat cell differentiation positive regulation of synaptic transmission negative regulation of feeding behavior positive regulation of smooth muscle cell proliferation neutrophil degranulation regulation of signaling receptor activity biological process signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56729 57264 Ensembl ENSG00000104918 ENSMUSG00000012705 UniProt Q9HD89 Q99P87 RefSeq (mRNA) NM_020415 NM_001193374 NM_001385725 NM_001385726 NM_001385727 NM_001204959 NM_022984 RefSeq (protein) NP_001180303 NP_065148 NP_001191888 NP_075360 Location (UCSC) Chr 19: 7.67 – 7.67 Mb Chr 8: 3.71 – 3.71 Mb PubMed search [3] [4]
Wikidata
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Resistin also known as adipose tissue-specific secretory factor (ADSF) or C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein (XCP1) is a cysteine-rich peptide hormone derived from adipose tissue that in humans is encoded by the RETN gene.^[5]

In primates, pigs, and dogs, resistin is secreted by immune and epithelial cells, while, in rodents, it is secreted by adipose tissue. The length of the resistin pre-peptide in human is 108 amino acid residues and in the mouse and rat it is 114 aa; the molecular weight is ~12.5 kDa. Resistin is an adipose-derived hormone (similar to a cytokine) whose physiologic role has been the subject of much controversy regarding its involvement with obesity and type II diabetes mellitus (T2DM).^[6]