Ritodrine

Ritodrine
Clinical data
Pronunciation	/ˈraɪtoʊdriːn/ RY-toh-dreen
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Routes of; administration	Oral (tablets), parenteral (IV)
ATC code	G02CA01 (WHO) ;
Legal status
Legal status	US: Discontinued;
Pharmacokinetic data
Protein binding	~56%
Metabolism	Hepatic, metabolites are inactive
Elimination half-life	1.7–2.6 hours
Identifiers
	IUPAC name 4-[2-[[(1R,2S)-1-hydroxy-1-(4-hydroxyphenyl)propan-2-yl]amino]ethyl]phenol;
CAS Number	26652-09-5 ;
PubChem CID	33572;
IUPHAR/BPS	7294;
DrugBank	DB00867 ;
ChemSpider	30971 ;
UNII	I0Q6O6740J;
KEGG	D02359 ;
ChEMBL	ChEMBL785 ;
CompTox Dashboard (EPA)	DTXSID7048534 ;
ECHA InfoCard	100.043.512
Chemical and physical data
Formula	C17H21NO3
Molar mass	287.359 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O[C@H](c1ccc(O)cc1)[C@@H](NCCc2ccc(O)cc2)C;
	InChI InChI=1S/C17H21NO3/c1-12(17(21)14-4-8-16(20)9-5-14)18-11-10-13-2-6-15(19)7-3-13/h2-9,12,17-21H,10-11H2,1H3/t12-,17-/m0/s1 ; Key:IOVGROKTTNBUGK-SJCJKPOMSA-N ;
	(verify)

Ritodrine (trade name Yutopar) is a tocolytic drug used to stop premature labor.^[2] This drug has been removed from the US market, according to FDA Orange Book. It was available in oral tablets or as an injection and was typically used as the hydrochloride salt, ritodrine hydrochloride.

^ Finkelstein, BW (1981). "Ritodrine (Yutopar, Merrell Dow Pharmaceuticals Inc.)". Drug Intelligence & Clinical Pharmacy. 15 (6): 425–33. doi:10.1177/106002808101500601. S2CID 75942075.
^ Li X, Zhang Y, Shi Z (February 2005). "Ritodrine in the treatment of preterm labour: a meta-analysis" (PDF). The Indian Journal of Medical Research. 121 (2): 120–7. PMID 15756046. Archived from the original (PDF) on 2019-08-25. Retrieved 2008-10-05.

[1] Finkelstein, BW (1981). "Ritodrine (Yutopar, Merrell Dow Pharmaceuticals Inc.)". Drug Intelligence & Clinical Pharmacy. 15 (6): 425–33. doi:10.1177/106002808101500601. S2CID 75942075.

[pmid15756046-2] Li X, Zhang Y, Shi Z (February 2005). "Ritodrine in the treatment of preterm labour: a meta-analysis" (PDF). The Indian Journal of Medical Research. 121 (2): 120–7. PMID 15756046. Archived from the original (PDF) on 2019-08-25. Retrieved 2008-10-05.

[1]

[2]

Clinical data


Pronunciation	/ˈraɪtoʊdriːn/ RY-toh-dreen
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Routes of administration	Oral (tablets), parenteral (IV)
ATC code	G02CA01 (WHO)
Legal status
Legal status	US: Discontinued
Pharmacokinetic data
Protein binding	~56%
Metabolism	Hepatic, metabolites are inactive^[1]
Elimination half-life	1.7–2.6 hours
Identifiers
IUPAC name 4-[2-[[(1R,2S)-1-hydroxy-1-(4-hydroxyphenyl)propan-2-yl]amino]ethyl]phenol
CAS Number	26652-09-5^Y
PubChem CID	33572
IUPHAR/BPS	7294
DrugBank	DB00867^Y
ChemSpider	30971^Y
UNII	I0Q6O6740J
KEGG	D02359^Y
ChEMBL	ChEMBL785^Y
CompTox Dashboard (EPA)	DTXSID7048534
ECHA InfoCard	100.043.512
Chemical and physical data
Formula	C₁₇H₂₁NO₃
Molar mass	287.359 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES O[C@H](c1ccc(O)cc1)[C@@H](NCCc2ccc(O)cc2)C
InChI InChI=1S/C17H21NO3/c1-12(17(21)14-4-8-16(20)9-5-14)18-11-10-13-2-6-15(19)7-3-13/h2-9,12,17-21H,10-11H2,1H3/t12-,17-/m0/s1^Y Key:IOVGROKTTNBUGK-SJCJKPOMSA-N^Y
(verify)