Rotigotine

Rotigotine
Clinical data
Trade names	Neupro, Leganto
AHFS/Drugs.com	Monograph
MedlinePlus	a607059
License data	US DailyMed: Rotigotine;
Pregnancy; category	AU: B3; ;
Routes of; administration	Transdermal patch
ATC code	N04BC09 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only); BR: Class C1 (Other controlled substances); US: ℞-only; EU: Rx-only; In general: ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	37% (transdermal)
Protein binding	92%
Metabolism	Liver (CYP-mediated)
Elimination half-life	5–7 hours
Excretion	Urine (71%), Feces (23%)
Identifiers
	IUPAC name (S)-6-[Propyl(2-thiophen-2-ylethyl)amino]-5,6,7,8- tetrahydronaphthalen-1-ol;
CAS Number	99755-59-6 ;
PubChem CID	57537;
IUPHAR/BPS	941;
DrugBank	DB05271 ;
ChemSpider	51867 ;
UNII	87T4T8BO2E;
KEGG	D05768;
ChEMBL	ChEMBL1303 ;
CompTox Dashboard (EPA)	DTXSID5046772 ;
ECHA InfoCard	100.123.257
Chemical and physical data
Formula	C19H25NOS
Molar mass	315.48 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Oc1cccc3c1CCC(N(CCC)CCc2sccc2)C3;
	InChI InChI=1S/C19H25NOS/c1-2-11-20(12-10-17-6-4-13-22-17)16-8-9-18-15(14-16)5-3-7-19(18)21/h3-7,13,16,21H,2,8-12,14H2,1H3 ; Key:KFQYTPMOWPVWEJ-UHFFFAOYSA-N ;
	(what is this?) (verify)

Rotigotine, sold under the brand name Neupro among others, is a dopamine agonist of the non-ergoline class of medications indicated for the treatment of Parkinson's disease and restless legs syndrome.^[3]^[4] It is formulated as a once-daily transdermal patch which provides a slow and constant supply of the drug over the course of 24 hours.^[3]

Like other dopamine agonists, rotigotine has been shown to possess antidepressant effects and may be useful in the treatment of depression as well.^[5]

^ Anvisa (31 March 2023). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 4 April 2023). Archived from the original on 3 August 2023. Retrieved 16 August 2023.
^ Cite error: The named reference Neupro EPAR was invoked but never defined (see the help page).
^ ^a ^b Chen JJ, Swope DM, Dashtipour K, Lyons KE (December 2009). "Transdermal rotigotine: a clinically innovative dopamine-receptor agonist for the management of Parkinson's disease". Pharmacotherapy. 29 (12): 1452–1467. doi:10.1592/phco.29.12.1452. PMID 19947805. S2CID 40466260.
^ Davies S (September 2009). "Rotigotine for restless legs syndrome". Drugs of Today. 45 (9): 663–668. doi:10.1358/dot.2009.45.9.1399952. PMID 19956807.
^ Bertaina-Anglade V, La Rochelle CD, Scheller DK (October 2006). "Antidepressant properties of rotigotine in experimental models of depression". European Journal of Pharmacology. 548 (1–3): 106–114. doi:10.1016/j.ejphar.2006.07.022. PMID 16959244.

[1] Anvisa (31 March 2023). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 4 April 2023). Archived from the original on 3 August 2023. Retrieved 16 August 2023.

[Neupro_EPAR-2] Cite error: The named reference Neupro EPAR was invoked but never defined (see the help page).

[pmid19947805-3] Chen JJ, Swope DM, Dashtipour K, Lyons KE (December 2009). "Transdermal rotigotine: a clinically innovative dopamine-receptor agonist for the management of Parkinson's disease". Pharmacotherapy. 29 (12): 1452–1467. doi:10.1592/phco.29.12.1452. PMID 19947805. S2CID 40466260.

[pmid19956807-4] Davies S (September 2009). "Rotigotine for restless legs syndrome". Drugs of Today. 45 (9): 663–668. doi:10.1358/dot.2009.45.9.1399952. PMID 19956807.

[pmid16959244-5] Bertaina-Anglade V, La Rochelle CD, Scheller DK (October 2006). "Antidepressant properties of rotigotine in experimental models of depression". European Journal of Pharmacology. 548 (1–3): 106–114. doi:10.1016/j.ejphar.2006.07.022. PMID 16959244.

[1]

[2]

[3]

[4]

[5]