S100 protein

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary
PDB	1yutB:9-52 1yuuA:9-52 1yusB:9-52 1yurA:9-52 1k8uA:5-50 1k9pA:5-50 1k96A:5-50 1k9kA:5-50 1cnpB:5-50 1a03A:5-50 2cnpB:5-50 1jwdB:5-50 1m31A:5-48 1k2hB:5-48 1cfpB:4-47 1psbA:4-47 1mho :4-47 1uwoA:4-47 1mq1B:4-47 1b4cB:4-47 1symA:4-47 1qlkB:4-47 1xydB:4-47 1dt7B:4-47 1mwnA:4-47 1j55A:4-47 1ozoA:4-47 1ksoA:5-48 1irjH:8-51 1xk4K:8-51 1gqmI:4-47 1odbD:4-47 1e8aB:4-47 1clb :5-46 1ig5A:5-46 2bca :5-46 1qx2B:5-46 1bod :5-46 1b1gA:5-46 1kcyA:5-46 1ht9A:5-46 2bcb :5-46 1n65A:5-46 1boc :5-46 3icb :5-46 1kqvA:5-46 1ksmA:5-46 1cdn :5-46 4icb :5-46 1igvA:5-46 1d1oA:5-46 1cb1 :4-46 1a4pB:5-45 1bt6A:5-45 1nshB:7-50 1v4zA:10-19 1v50A:10-19 1qlsA:8-51 1mr8B:5-48 1psrB:6-46 2psr :6-46 3psrA:6-46

S100/ICaBP type calcium binding domain
S100/ICaBP type calcium binding domain
	Structure of the S100B protein. Based on PyMOL rendering of PDB 1b4c.
Identifiers
Symbol	S_100
Pfam	PF01023
InterPro	IPR013787
PROSITE	PDOC00275
SCOP2	1cnp / SCOPe / SUPFAM
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary
PDB	1yutB:9-52 1yuuA:9-52 1yusB:9-52 1yurA:9-52 1k8uA:5-50 1k9pA:5-50 1k96A:5-50 1k9kA:5-50 1cnpB:5-50 1a03A:5-50 2cnpB:5-50 1jwdB:5-50 1m31A:5-48 1k2hB:5-48 1cfpB:4-47 1psbA:4-47 1mho :4-47 1uwoA:4-47 1mq1B:4-47 1b4cB:4-47 1symA:4-47 1qlkB:4-47 1xydB:4-47 1dt7B:4-47 1mwnA:4-47 1j55A:4-47 1ozoA:4-47 1ksoA:5-48 1irjH:8-51 1xk4K:8-51 1gqmI:4-47 1odbD:4-47 1e8aB:4-47 1clb :5-46 1ig5A:5-46 2bca :5-46 1qx2B:5-46 1bod :5-46 1b1gA:5-46 1kcyA:5-46 1ht9A:5-46 2bcb :5-46 1n65A:5-46 1boc :5-46 3icb :5-46 1kqvA:5-46 1ksmA:5-46 1cdn :5-46 4icb :5-46 1igvA:5-46 1d1oA:5-46 1cb1 :4-46 1a4pB:5-45 1bt6A:5-45 1nshB:7-50 1v4zA:10-19 1v50A:10-19 1qlsA:8-51 1mr8B:5-48 1psrB:6-46 2psr :6-46 3psrA:6-46

The S100 proteins are a family of low molecular-weight proteins found in vertebrates characterized by two calcium-binding sites that have helix-loop-helix ("EF-hand-type") conformation. At least 21 different S100 proteins are known.^[1] They are encoded by a family of genes whose symbols use the S100 prefix, for example, S100A1, S100A2, S100A3. They are also considered as damage-associated molecular pattern molecules (DAMPs), and knockdown of aryl hydrocarbon receptor downregulates the expression of S100 proteins in THP-1 cells.^[2]

^ Marenholz I, Heizmann CW, Fritz G (2004). "S100 proteins in mouse and man: from evolution to function and pathology (including an update of the nomenclature)". Biochemical and Biophysical Research Communications. 322 (4): 1111–22. doi:10.1016/j.bbrc.2004.07.096. PMID 15336958.
^ Memari B, Bouttier M, Dimitrov V, Ouellette M, Behr MA, Fritz JH, White JH (2015). "Engagement of the Aryl Hydrocarbon Receptor in Mycobacterium tuberculosis-Infected Macrophages Has Pleiotropic Effects on Innate Immune Signaling". Journal of Immunology. 195 (9): 4479–91. doi:10.4049/jimmunol.1501141. PMID 26416282.