SIGLEC6

SIGLEC6
Identifiers
Aliases	SIGLEC6, CD327, CD33L, CD33L1, CD33L2, CDW327, OBBP1, sialic acid binding Ig like lectin 6
External IDs	OMIM: 604405; HomoloGene: 130495; GeneCards: SIGLEC6; OMA:SIGLEC6 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	51,531,856 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; placenta; ; tibialis anterior muscle; ; rectum; ; pancreatic ductal cell; ; gallbladder; ; mucosa of ileum; ; lymph node; ; appendix; ; smooth muscle tissue;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; carbohydrate binding;
Cellular component	integral component of membrane; extracellular region; plasma membrane; integral component of plasma membrane; membrane;
Biological process	cell-cell signaling; cell adhesion;
	Sources:Amigo / QuickGO
Orthologs
	946
	n/a
	ENSG00000105492
	n/a
	O43699
	n/a
NM_001177547; NM_001177548; NM_001177549; NM_001245; NM_198845;
	NM_198846
	n/a
NP_001171018; NP_001171019; NP_001171020; NP_001236; NP_942142;
	NP_942143
	n/a
	Wikidata
View/Edit Human

Sialic acid-binding Ig-like lectin 6 is a protein that in humans is encoded by the SIGLEC6 gene.^[3] The gene was originally named CD33L (CD33-like) due to similarities between these genes but later became known as OB-BP1 (OB [leptin]-binding protein 1) due to its ability to bind to this factor and, finally, SIGLEC6 as the sixth member of the SIGLEC family of receptors to be identified.^[4] The protein has also been given the CD designation CD327.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000105492 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Takei Y, Sasaki S, Fujiwara T, Takahashi E, Muto T, Nakamura Y (1997). "Molecular cloning of a novel gene similar to myeloid antigen CD33 and its specific expression in placenta". Cytogenetic and Genome Research. 78 (3–4): 295–300. doi:10.1159/000134676. PMID 9465907.
^ Patel N, Brinkman-Van der Linden EC, Altmann SW, Gish K, Balasubramanian S, Timans JC, Peterson D, Bell MP, Bazan JF, Varki A, Kastelein RA (August 1999). "OB-BP1/Siglec-6. a leptin- and sialic acid-binding protein of the immunoglobulin superfamily". Journal of Biological Chemistry. 274 (32): 22729–38. doi:10.1074/jbc.274.32.22729. PMID 10428856.
^ Zola H, Swart B, Banham A, Barry S, Beare A, Bensussan A, Boumsell L, Buckley CD, Buhring HJ, Clark G, Engel P, Fox D, Jin BQ, Macardle PJ, Malavasi F, Mason D, Stockinger H, Yang X (January 2007). "CD molecules 2006--human cell differentiation molecules". Journal of Immunological Methods. 319 (1–2): 1–5. doi:10.1016/j.jim.2006.11.001. PMID 17174972.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000105492 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9465907-3] Takei Y, Sasaki S, Fujiwara T, Takahashi E, Muto T, Nakamura Y (1997). "Molecular cloning of a novel gene similar to myeloid antigen CD33 and its specific expression in placenta". Cytogenetic and Genome Research. 78 (3–4): 295–300. doi:10.1159/000134676. PMID 9465907.

[pmid10428856-4] Patel N, Brinkman-Van der Linden EC, Altmann SW, Gish K, Balasubramanian S, Timans JC, Peterson D, Bell MP, Bazan JF, Varki A, Kastelein RA (August 1999). "OB-BP1/Siglec-6. a leptin- and sialic acid-binding protein of the immunoglobulin superfamily". Journal of Biological Chemistry. 274 (32): 22729–38. doi:10.1074/jbc.274.32.22729. PMID 10428856.

[pmid17174972-5] Zola H, Swart B, Banham A, Barry S, Beare A, Bensussan A, Boumsell L, Buckley CD, Buhring HJ, Clark G, Engel P, Fox D, Jin BQ, Macardle PJ, Malavasi F, Mason D, Stockinger H, Yang X (January 2007). "CD molecules 2006--human cell differentiation molecules". Journal of Immunological Methods. 319 (1–2): 1–5. doi:10.1016/j.jim.2006.11.001. PMID 17174972.

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