SLAMF1

SLAMF1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1M27, 1KA7, 1I3Z, 1D4T, 1D4W, 1KA6
Identifiers
Aliases	SLAMF1, CD150, CDw150, SLAM, signaling lymphocytic activation molecule family member 1
External IDs	OMIM: 603492; MGI: 1351314; HomoloGene: 48162; GeneCards: SLAMF1; OMA:SLAMF1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	160,647,044 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	171,628,752 bp
RNA expression pattern
	Top expressed in
	thymus; ; lymph node; ; granulocyte; ; appendix; ; blood; ; tonsil; ; bone marrow cells; ; spleen; ; rectum; ; pancreatic ductal cell;
	Top expressed in
	blood; ; thymus; ; zygote; ; secondary oocyte; ; primary oocyte; ; tibiofemoral joint; ; spleen; ; mesenteric lymph nodes; ; embryo; ; embryo;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	antigen binding; virus receptor activity; protein binding; transmembrane signaling receptor activity; identical protein binding; signaling receptor activity;
Cellular component	integral component of membrane; membrane; plasma membrane; extracellular region; cell surface; phagocytic vesicle; extracellular exosome; external side of plasma membrane;
Biological process	adaptive immune response; immune system process; natural killer cell proliferation; T-helper 1 cell cytokine production; negative regulation of interleukin-6 production; positive regulation of JNK cascade; cell adhesion; negative regulation of CD40 signaling pathway; negative regulation of T cell cytokine production; myeloid dendritic cell activation involved in immune response; regulation of vesicle fusion; positive regulation of cell population proliferation; positive regulation of ERK1 and ERK2 cascade; phagocytosis; lymphocyte activation; viral entry into host cell; negative regulation of tumor necrosis factor production; innate immune response; regulation of catalytic activity; viral process; positive regulation of activated T cell proliferation; negative regulation of interleukin-12 production; natural killer cell differentiation; signal transduction; leukocyte chemotaxis involved in inflammatory response; positive regulation of macrophage chemotaxis; positive regulation of dendritic cell chemotaxis;
	Sources:Amigo / QuickGO
Orthologs
	6504
	27218
	ENSG00000117090
	ENSMUSG00000015316
	Q13291
	Q9QUM4
	NM_003037; NM_001330754
	NM_013730; NM_001360898
	NP_001317683; NP_003028
	NP_038758; NP_001347827
	Wikidata
View/Edit Human	View/Edit Mouse

Signaling lymphocytic activation molecule 1 is a protein that in humans is encoded by the SLAMF1 gene.^[5]^[6] Recently SLAMF1 has also been designated CD150 (cluster of differentiation 150).

SLAMF1 belongs to the signaling lymphocytic activation molecule family. As other receptors from this family, SLAMF1 is expressed in different types of hematopoietic cells and it plays a role in the regulation of the immune system.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000117090 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000015316 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Cocks BG, Chang CC, Carballido JM, Yssel H, de Vries JE, Aversa G (July 1995). "A novel receptor involved in T-cell activation". Nature. 376 (6537): 260–263. Bibcode:1995Natur.376..260C. doi:10.1038/376260a0. PMID 7617038. S2CID 4319295.
^ "Entrez Gene: SLAMF1 signaling lymphocytic activation molecule family member 1".
^ Gordiienko I, Shlapatska L, Kovalevska L, Sidorenko SP (July 2019). "SLAMF1/CD150 in hematologic malignancies: Silent marker or active player?". Clinical Immunology. 204: 14–22. doi:10.1016/j.clim.2018.10.015. PMID 30616923. S2CID 58586790.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000117090 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000015316 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7617038-5] Cocks BG, Chang CC, Carballido JM, Yssel H, de Vries JE, Aversa G (July 1995). "A novel receptor involved in T-cell activation". Nature. 376 (6537): 260–263. Bibcode:1995Natur.376..260C. doi:10.1038/376260a0. PMID 7617038. S2CID 4319295.

[entrez-6] "Entrez Gene: SLAMF1 signaling lymphocytic activation molecule family member 1".

[Gordiienko_2019-7] Gordiienko I, Shlapatska L, Kovalevska L, Sidorenko SP (July 2019). "SLAMF1/CD150 in hematologic malignancies: Silent marker or active player?". Clinical Immunology. 204: 14–22. doi:10.1016/j.clim.2018.10.015. PMID 30616923. S2CID 58586790.

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