SORBS2

SORBS2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4IGZ
Identifiers
Aliases	SORBS2, ARGBP2, PRO0618, sorbin and SH3 domain containing 2
External IDs	OMIM: 616349; MGI: 1924574; HomoloGene: 83295; GeneCards: SORBS2; OMA:SORBS2 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	185,956,652 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	46,280,943 bp
RNA expression pattern
	Top expressed in
	right ventricle; ; popliteal artery; ; right coronary artery; ; retinal pigment epithelium; ; left coronary artery; ; vena cava; ; thyroid gland; ; ascending aorta; ; left lobe of thyroid gland; ; right lobe of thyroid gland;
	Top expressed in
	otolith organ; ; utricle; ; myocardium of ventricle; ; atrioventricular valve; ; atrium; ; parotid gland; ; piriform cortex; ; left ventricle; ; amygdala; ; submandibular gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	structural constituent of cytoskeleton; protein binding; cytoskeletal anchor activity; structural constituent of muscle; RNA binding; nucleic acid binding;
Cellular component	cytoplasm; cell projection; membrane; focal adhesion; plasma membrane; cell junction; Z disc; apical plasma membrane; actin cytoskeleton; perinuclear region of cytoplasm; nucleus; lamellipodium; nucleoplasm;
Biological process	cell growth involved in cardiac muscle cell development; actin filament organization; Notch signaling pathway; biological process;
	Sources:Amigo / QuickGO
Orthologs
	8470
	234214
	ENSG00000154556
	ENSMUSG00000031626
	O94875
	Q3UTJ2
NM_001145670; NM_001145671; NM_001145672; NM_001145673; NM_001145674;
	NM_001145675; NM_001270771; NM_003603; NM_021069
	NM_001205219; NM_172752; NM_001310707; NM_001310708
NP_001139142; NP_001139143; NP_001139144; NP_001139145; NP_001139146;
	NP_001139147; NP_001257700; NP_003594; NP_066547
NP_001192148; NP_001297636; NP_001297637; NP_766340; NP_001389592;
	NP_001389593; NP_001389594; NP_001389595; NP_001389596; NP_001389597; NP_001389598; NP_001389599; NP_001389600; NP_001389601; NP_001389602; NP_001389603; NP_001389604
	Wikidata
View/Edit Human	View/Edit Mouse

ArgBP2 protein, also referred to as Sorbin and SH3 domain-containing protein 2 is a protein that in humans is encoded by the SORBS2 gene.^[5]^[6] ArgBP2 belongs to the a small family of adaptor proteins having sorbin homology (SOHO) domains. ArgBP2 is highly abundant in cardiac muscle cells at sarcomeric Z-disc structures, and is expressed in other cells at actin stress fibers and the nucleus.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000154556 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031626 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wang B, Golemis EA, Kruh GD (Jul 1997). "ArgBP2, a multiple Src homology 3 domain-containing, Arg/Abl-interacting protein, is phosphorylated in v-Abl-transformed cells and localized in stress fibers and cardiocyte Z-disks". The Journal of Biological Chemistry. 272 (28): 17542–50. doi:10.1074/jbc.272.28.17542. hdl:20.500.12613/9174. PMID 9211900.
^ "Entrez Gene: SORBS2 sorbin and SH3 domain containing 2".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000154556 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031626 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9211900-5] Wang B, Golemis EA, Kruh GD (Jul 1997). "ArgBP2, a multiple Src homology 3 domain-containing, Arg/Abl-interacting protein, is phosphorylated in v-Abl-transformed cells and localized in stress fibers and cardiocyte Z-disks". The Journal of Biological Chemistry. 272 (28): 17542–50. doi:10.1074/jbc.272.28.17542. hdl:20.500.12613/9174. PMID 9211900.

[entrez-6] "Entrez Gene: SORBS2 sorbin and SH3 domain containing 2".

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