Secretomics

Secretomics is a type of proteomics which involves the analysis of the secretome—all the secreted proteins of a cell, tissue or organism.^[1] Secreted proteins are involved in a variety of physiological processes, including cell signaling and matrix remodeling, but are also integral to invasion and metastasis of malignant cells.^[2] Secretomics has thus been especially important in the discovery of biomarkers for cancer^[3] and understanding molecular basis of pathogenesis.^[4]^[5] The analysis of the insoluble fraction of the secretome (the extracellular matrix) has been termed matrisomics.^[6]

^ Hathout, Yetrib (2007). "Approaches to the study of the cell secretome". Expert Review of Proteomics. 4 (2): 239–48. doi:10.1586/14789450.4.2.239. PMID 17425459.
^ Pavlou, Maria P.; Diamandis, Eleftherios P. (2010). "The cancer cell secretome: A good source for discovering biomarkers?". Journal of Proteomics. 73 (10): 1896–906. doi:10.1016/j.jprot.2010.04.003. PMID 20394844.
^ Grønborg, Mads; Kristiansen, Troels Zakarias; Iwahori, Akiko; Chang, Rubens; Reddy, Raghunath; Sato, Norihiro; Molina, Henrik; Jensen, Ole Nørregaard; Hruban, Ralph H. (January 2006). "Biomarker discovery from pancreatic cancer secretome using a differential proteomic approach". Molecular & Cellular Proteomics. 5 (1): 157–171. doi:10.1074/mcp.M500178-MCP200. ISSN 1535-9476. PMID 16215274.
^ Khan, Mohd M.; Ernst, Orna; Sun, Jing; Fraser, Iain D. C.; Ernst, Robert K.; Goodlett, David R.; Nita-Lazar, Aleksandra (2018-06-24). "Mass Spectrometry-based Structural Analysis and Systems Immunoproteomics Strategies for Deciphering the Host Response to Endotoxin". Journal of Molecular Biology. 430 (17): 2641–2660. doi:10.1016/j.jmb.2018.06.032. ISSN 1089-8638. PMID 29949751.
^ Khan, Mohd M.; Koppenol-Raab, Marijke; Kuriakose, Minna; Manes, Nathan P.; Goodlett, David R.; Nita-Lazar, Aleksandra (2018-03-20). "Host-pathogen dynamics through targeted secretome analysis of stimulated macrophages". Journal of Proteomics. 189: 34–38. doi:10.1016/j.jprot.2018.03.016. ISSN 1876-7737. PMC 6149218. PMID 29572161.
^ Hynes, R. O.; Naba, A. (21 September 2011). "Overview of the Matrisome--An Inventory of Extracellular Matrix Constituents and Functions". Cold Spring Harbor Perspectives in Biology. 4 (1): a004903. doi:10.1101/cshperspect.a004903. PMC 3249625. PMID 21937732.

[pmid17425459-1] Hathout, Yetrib (2007). "Approaches to the study of the cell secretome". Expert Review of Proteomics. 4 (2): 239–48. doi:10.1586/14789450.4.2.239. PMID 17425459.

[pmid20394844-2] Pavlou, Maria P.; Diamandis, Eleftherios P. (2010). "The cancer cell secretome: A good source for discovering biomarkers?". Journal of Proteomics. 73 (10): 1896–906. doi:10.1016/j.jprot.2010.04.003. PMID 20394844.

[3] Grønborg, Mads; Kristiansen, Troels Zakarias; Iwahori, Akiko; Chang, Rubens; Reddy, Raghunath; Sato, Norihiro; Molina, Henrik; Jensen, Ole Nørregaard; Hruban, Ralph H. (January 2006). "Biomarker discovery from pancreatic cancer secretome using a differential proteomic approach". Molecular & Cellular Proteomics. 5 (1): 157–171. doi:10.1074/mcp.M500178-MCP200. ISSN 1535-9476. PMID 16215274.

[4] Khan, Mohd M.; Ernst, Orna; Sun, Jing; Fraser, Iain D. C.; Ernst, Robert K.; Goodlett, David R.; Nita-Lazar, Aleksandra (2018-06-24). "Mass Spectrometry-based Structural Analysis and Systems Immunoproteomics Strategies for Deciphering the Host Response to Endotoxin". Journal of Molecular Biology. 430 (17): 2641–2660. doi:10.1016/j.jmb.2018.06.032. ISSN 1089-8638. PMID 29949751.

[5] Khan, Mohd M.; Koppenol-Raab, Marijke; Kuriakose, Minna; Manes, Nathan P.; Goodlett, David R.; Nita-Lazar, Aleksandra (2018-03-20). "Host-pathogen dynamics through targeted secretome analysis of stimulated macrophages". Journal of Proteomics. 189: 34–38. doi:10.1016/j.jprot.2018.03.016. ISSN 1876-7737. PMC 6149218. PMID 29572161.

[6] Hynes, R. O.; Naba, A. (21 September 2011). "Overview of the Matrisome--An Inventory of Extracellular Matrix Constituents and Functions". Cold Spring Harbor Perspectives in Biology. 4 (1): a004903. doi:10.1101/cshperspect.a004903. PMC 3249625. PMID 21937732.

[1]

[2]

[3]

[4]

[5]

[6]