Serum B-cell maturation antigen

TNFRSF17
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1OQD, 1XU2, 2KN1, 4ZFO
Identifiers
Aliases	TNFRSF17, BCM, BCMA, CD269, TNFRSF13A, tumor necrosis factor receptor superfamily member 17, TNF receptor superfamily member 17
External IDs	OMIM: 109545; MGI: 1343050; HomoloGene: 920; GeneCards: TNFRSF17; OMA:TNFRSF17 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	11,968,068 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	11,137,938 bp
RNA expression pattern
	Top expressed in
	rectum; ; mucosa of transverse colon; ; jejunal mucosa; ; mucosa of sigmoid colon; ; testicle; ; lymph node; ; epithelium of nasopharynx; ; appendix; ; spleen; ; duodenum;
	Top expressed in
	blastocyst; ; morula; ; duodenum; ; jejunum; ; spleen; ; lip; ; thymus; ; secondary oocyte; ; colon; ; ileum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	signaling receptor activity;
Cellular component	endomembrane system; plasma membrane; membrane; integral component of membrane;
Biological process	multicellular organism development; tumor necrosis factor-mediated signaling pathway; lymphocyte homeostasis; cell population proliferation; immune system process; adaptive immune response; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	608
	21935
	ENSG00000048462
	ENSMUSG00000022496
	Q02223
	O88472
	NM_001192
	NM_011608
	NP_001183
	NP_035738
	Wikidata
View/Edit Human	View/Edit Mouse

Serum B-cell maturation antigen (sBCMA) is the cleaved form of B-cell maturation antigen (BCMA), found at low levels in the serum of normal patients and generally elevated in patients with multiple myeloma (MM).^[5] Changes in sBCMA levels have been found to correlate with a MM patient’s clinical status in response to treatment.^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000048462 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022496 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Maglione PJ, Ko HM, Tokuyama M, Gyimesi G, Soof C, Li M, et al. (January 2020). "Serum B-Cell Maturation Antigen (BCMA) Levels Differentiate Primary Antibody Deficiencies". The Journal of Allergy and Clinical Immunology: In Practice. 8 (1): 283–291.e1. doi:10.1016/j.jaip.2019.08.012. PMC 6980522. PMID 31430592.
^ Sanchez E, Li M, Kitto A, Li J, Wang CS, Kirk DT, et al. (September 2012). "Serum B-cell maturation antigen is elevated in multiple myeloma and correlates with disease status and survival". British Journal of Haematology. 158 (6): 727–38. doi:10.1111/j.1365-2141.2012.09241.x. PMID 22804669. S2CID 30678354.
^ Ghermezi M, Li M, Vardanyan S, Harutyunyan NM, Gottlieb J, Berenson A, et al. (April 2017). "Serum B-cell maturation antigen: a novel biomarker to predict outcomes for multiple myeloma patients". Haematologica. 102 (4): 785–795. doi:10.3324/haematol.2016.150896. PMC 5395119. PMID 28034989.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000048462 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022496 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Maglione PJ, Ko HM, Tokuyama M, Gyimesi G, Soof C, Li M, et al. (January 2020). "Serum B-Cell Maturation Antigen (BCMA) Levels Differentiate Primary Antibody Deficiencies". The Journal of Allergy and Clinical Immunology: In Practice. 8 (1): 283–291.e1. doi:10.1016/j.jaip.2019.08.012. PMC 6980522. PMID 31430592.

[Serum_B-cell_maturation_antigen_is-6] Sanchez E, Li M, Kitto A, Li J, Wang CS, Kirk DT, et al. (September 2012). "Serum B-cell maturation antigen is elevated in multiple myeloma and correlates with disease status and survival". British Journal of Haematology. 158 (6): 727–38. doi:10.1111/j.1365-2141.2012.09241.x. PMID 22804669. S2CID 30678354.

[Serum_B-cell_maturation_antigen:_a-7] Ghermezi M, Li M, Vardanyan S, Harutyunyan NM, Gottlieb J, Berenson A, et al. (April 2017). "Serum B-cell maturation antigen: a novel biomarker to predict outcomes for multiple myeloma patients". Haematologica. 102 (4): 785–795. doi:10.3324/haematol.2016.150896. PMC 5395119. PMID 28034989.

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