Serum response factor

SRF
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1HBX, 1K6O, 1SRS
Identifiers
Aliases	SRF, MCM1, serum response factor
External IDs	OMIM: 600589; MGI: 106658; HomoloGene: 31135; GeneCards: SRF; OMA:SRF - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	43,181,506 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	46,867,101 bp
RNA expression pattern
	Top expressed in
	muscle layer of sigmoid colon; ; left uterine tube; ; popliteal artery; ; tibial arteries; ; right coronary artery; ; saphenous vein; ; body of uterus; ; right auricle; ; gastric mucosa; ; thoracic aorta;
	Top expressed in
	tail of embryo; ; genital tubercle; ; zygote; ; muscle of thigh; ; lip; ; superior frontal gyrus; ; granulocyte; ; primary visual cortex; ; dentate gyrus of hippocampal formation granule cell; ; skeletal muscle tissue;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein dimerization activity; DNA-binding transcription factor activity; DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II general transcription initiation factor activity; primary miRNA binding; transcription factor binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; protein homodimerization activity; serum response element binding; chromatin binding; protein binding; DNA binding; sequence-specific DNA binding; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; chromatin DNA binding; transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding; cis-regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; histone deacetylase binding; RNA polymerase II-specific DNA-binding transcription factor binding;
Cellular component	cytoplasm; nucleus; nucleoplasm;
Biological process	dorsal aorta morphogenesis; bronchus cartilage development; muscle cell cellular homeostasis; lung smooth muscle development; regulation of water loss via skin; transcription by RNA polymerase II; stress fiber assembly; cell migration involved in sprouting angiogenesis; platelet activation; cardiac myofibril assembly; heart looping; cellular senescence; face development; regulation of cell adhesion; long-term depression; neuron projection development; morphogenesis of an epithelial sheet; positive regulation of filopodium assembly; primitive streak formation; cellular response to glucose stimulus; negative regulation of cell population proliferation; response to cytokine; regulation of transcription, DNA-templated; heart trabecula formation; actin filament organization; thymus development; angiogenesis involved in wound healing; platelet formation; neuron development; in utero embryonic development; transcription, DNA-templated; positive regulation of transcription, DNA-templated; heart development; positive regulation of cell differentiation; branching involved in blood vessel morphogenesis; positive regulation of axon extension; positive regulation of smooth muscle contraction; trachea cartilage development; response to toxic substance; positive regulation of pri-miRNA transcription by RNA polymerase II; positive regulation of transcription by glucose; regulation of smooth muscle cell differentiation; epithelial structure maintenance; associative learning; skin morphogenesis; positive regulation of DNA-binding transcription factor activity; epithelial cell-cell adhesion; neuron migration; positive regulation of transcription initiation from RNA polymerase II promoter; eyelid development in camera-type eye; thyroid gland development; negative regulation of amyloid-beta clearance; negative regulation of cell migration; developmental growth; hematopoietic stem cell differentiation; gastrulation; trophectodermal cell differentiation; positive thymic T cell selection; response to hormone; cell-matrix adhesion; sarcomere organization; actin cytoskeleton organization; megakaryocyte development; response to hypoxia; lung morphogenesis; mesoderm formation; cardiac vascular smooth muscle cell differentiation; mRNA transcription by RNA polymerase II; multicellular organism development; tangential migration from the subventricular zone to the olfactory bulb; long-term memory; contractile actin filament bundle assembly; bicellular tight junction assembly; leukocyte differentiation; hippocampus development; positive regulation of transcription by RNA polymerase II; erythrocyte development; negative regulation of pri-miRNA transcription by RNA polymerase II; forebrain development; cell-cell adhesion;
	Sources:Amigo / QuickGO
Orthologs
	6722
	20807
	ENSG00000112658
	ENSMUSG00000015605
	P11831
	Q9JM73
	NM_003131; NM_001292001
	NM_020493
	NP_001278930; NP_003122; NP_003122.1
	NP_065239
	Wikidata
View/Edit Human	View/Edit Mouse

Serum response factor, also known as SRF, is a transcription factor protein.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000112658 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000015605 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Norman C, Runswick M, Pollock R, Treisman R (December 1988). "Isolation and properties of cDNA clones encoding SRF, a transcription factor that binds to the c-fos serum response element". Cell. 55 (6): 989–1003. doi:10.1016/0092-8674(88)90244-9. PMID 3203386. S2CID 20004673.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000112658 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000015605 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid3203386-5] Norman C, Runswick M, Pollock R, Treisman R (December 1988). "Isolation and properties of cDNA clones encoding SRF, a transcription factor that binds to the c-fos serum response element". Cell. 55 (6): 989–1003. doi:10.1016/0092-8674(88)90244-9. PMID 3203386. S2CID 20004673.

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