Shiga toxin

Shiga-like toxin subunit A
Shiga-like toxin subunit A
Identifiers
Symbol	Shiga-like_toxin_subunit_A
InterPro	IPR016331
SCOP2	1r4q / SCOPe / SUPFAM

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Shiga-like toxin beta subunit
Shiga-like toxin beta subunit
Identifiers
Symbol	SLT_beta
Pfam	PF02258
InterPro	IPR003189
SCOP2	2bos / SCOPe / SUPFAM
TCDB	1.C.54
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Shiga toxins are a family of related toxins with two major groups, Stx1 and Stx2, expressed by genes considered to be part of the genome of lambdoid prophages.^[1] The toxins are named after Kiyoshi Shiga, who first described the bacterial origin of dysentery caused by Shigella dysenteriae.^[2] Shiga-like toxin (SLT) is a historical term for similar or identical toxins produced by Escherichia coli.^[3] The most common sources for Shiga toxin are the bacteria S. dysenteriae and some serotypes of Escherichia coli (shigatoxigenic or STEC), which include serotypes O157:H7, and O104:H4.^[4]^[5]

^ Friedman D; Court D (2001). "Bacteriophage lambda: alive and well and still doing its thing". Current Opinion in Microbiology. 4 (2): 201–7. doi:10.1016/S1369-5274(00)00189-2. PMID 11282477.
^ Trofa, Andrew F.; Ueno-Olsen, Hannah; Oiwa, Ruiko; Yoshikawa, Masanosuke (1999-11-01). "Dr. Kiyoshi Shiga: Discoverer of the Dysentery Bacillus". Clinical Infectious Diseases. 29 (5): 1303–1306. doi:10.1086/313437. ISSN 1058-4838. PMID 10524979.
^ Zhu Q; Li L; Guo Z; Yang R (June 2002). "Identification of Shiga-like toxin Escherichia coli isolated from children with diarrhea by polymerase chain reaction". Chin. Med. J. 115 (6): 815–8. PMID 12123543.
^ Beutin L (2006). "Emerging enterohaemorrhagic Escherichia coli, causes and effects of the rise of a human pathogen". Journal of Veterinary Medicine, Series B. 53 (7): 299–305. doi:10.1111/j.1439-0450.2006.00968.x. PMID 16930272.
^ Spears KJ, Roe AJ, Gally DL (2006). "A comparison of enteropathogenic and enterohaemorragic Escherichia coli pathogenesis". FEMS Microbiology Letters. 255 (2): 187–202. doi:10.1111/j.1574-6968.2006.00119.x. PMID 16448495.

[Friedman_2001-1] Friedman D; Court D (2001). "Bacteriophage lambda: alive and well and still doing its thing". Current Opinion in Microbiology. 4 (2): 201–7. doi:10.1016/S1369-5274(00)00189-2. PMID 11282477.

[shiga-nom-2] Trofa, Andrew F.; Ueno-Olsen, Hannah; Oiwa, Ruiko; Yoshikawa, Masanosuke (1999-11-01). "Dr. Kiyoshi Shiga: Discoverer of the Dysentery Bacillus". Clinical Infectious Diseases. 29 (5): 1303–1306. doi:10.1086/313437. ISSN 1058-4838. PMID 10524979.

[pmid12123543-3] Zhu Q; Li L; Guo Z; Yang R (June 2002). "Identification of Shiga-like toxin Escherichia coli isolated from children with diarrhea by polymerase chain reaction". Chin. Med. J. 115 (6): 815–8. PMID 12123543.

[Beutin_2006-4] Beutin L (2006). "Emerging enterohaemorrhagic Escherichia coli, causes and effects of the rise of a human pathogen". Journal of Veterinary Medicine, Series B. 53 (7): 299–305. doi:10.1111/j.1439-0450.2006.00968.x. PMID 16930272.

[5] Spears KJ, Roe AJ, Gally DL (2006). "A comparison of enteropathogenic and enterohaemorragic Escherichia coli pathogenesis". FEMS Microbiology Letters. 255 (2): 187–202. doi:10.1111/j.1574-6968.2006.00119.x. PMID 16448495.

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