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Signal transducing adaptor proteins (STAPs) are proteins that are accessory to main proteins in a signal transduction pathway.[1] Adaptor proteins contain a variety of protein-binding modules that link protein-binding partners together and facilitate the creation of larger signaling complexes. These proteins tend to lack any intrinsic enzymatic activity themselves,[2] instead mediating specific protein–protein interactions that drive the formation of protein complexes. Examples of adaptor proteins include MYD88,[3][4] Grb2 and SHC1.
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