Signaling lymphocytic activation molecule | |||||||||
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Identifiers | |||||||||
Symbol | SLAM | ||||||||
Pfam | PF06214 | ||||||||
InterPro | IPR010407 | ||||||||
Membranome | 164 | ||||||||
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Signaling lymphocytic activation molecule (SLAM) is a family of genes. Homophilic binding between SLAMs is involved in cell-to-cell adhesion during antigen presentation. [1][2]
Signaling lymphocytic activation molecules are a CD2-related surface receptor expressed by activated phagocytes, T helper cells, and platelets.[3] SLAMs have a variety of functions, including enhancing T cellular proliferation by stimulating IL-4 and IFN-gamma production.[4] SLAM family (SLAMF) receptors can interact directly with microbes, which can cause phagocytic cells to migrate to the area.[5] SLAMF activation can trigger SLAM-associated protein (SAP) activation and a defective SAP can cause X-linked lymphoproliferative syndrome (XLP).[4]
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