| Signaling lymphocytic activation molecule | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | SLAM | ||||||||
| Pfam | PF06214 | ||||||||
| InterPro | IPR010407 | ||||||||
| Membranome | 164 | ||||||||
| |||||||||
Signaling lymphocytic activation molecule (SLAM) is a family of genes. Homophilic binding between SLAMs is involved in cell-to-cell adhesion during antigen presentation. [1][2]
Signaling lymphocytic activation molecules are a CD2-related surface receptor expressed by activated phagocytes, T helper cells, and platelets.[3] SLAMs have a variety of functions, including enhancing T cellular proliferation by stimulating IL-4 and IFN-gamma production.[4] SLAM family (SLAMF) receptors can interact directly with microbes, which can cause phagocytic cells to migrate to the area.[5] SLAMF activation can trigger SLAM-associated protein (SAP) activation and a defective SAP can cause X-linked lymphoproliferative syndrome (XLP).[4]
- ^ "SLAM FAMILY, MEMBER 1". OMIM. Retrieved 19 March 2014.
- ^ Rosenbach T, Csatò M, Czarnetzki BM (January 1988). "Studies on the role of leukotrienes in murine allergic and irritant contact dermatitis". The British Journal of Dermatology. 118 (1): 1–6. doi:10.1111/j.1365-2133.1988.tb01743.x. PMID 2829957. S2CID 1164113.
- ^ Cite error: The named reference
:24was invoked but never defined (see the help page). - ^ a b Cite error: The named reference
:12was invoked but never defined (see the help page). - ^ van Driel BJ, Liao G, Engel P, Terhorst C (2016-01-20). "Responses to Microbial Challenges by SLAMF Receptors". Frontiers in Immunology. 7: 4. doi:10.3389/fimmu.2016.00004. PMC 4718992. PMID 26834746.
© MMXXIII Rich X Search. We shall prevail. All rights reserved. Rich X Search