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Streptomycin

Streptomycin
Clinical data
Other namesS/STR/STS[1]
AHFS/Drugs.comMonograph
License data
Routes of
administration		Intramuscular, intravenous
ATC code
Legal status
Legal status
  • AU: S4 (Prescription only)
  • UK: POM (Prescription only)
  • US: ℞-only
Pharmacokinetic data
Bioavailability84% to 88% IM (est.)[2] 0% by mouth
Elimination half-life5 to 6 hours
ExcretionKidney
Identifiers
  • 5-(2,4-diguanidino-
    3,5,6-trihydroxy-cyclohexoxy)- 4-[4,5-dihydroxy-6-(hydroxymethyl)
    -3-methylamino-tetrahydropyran-2-yl] oxy-3-hydroxy-2-methyl
    -tetrahydrofuran-3-carbaldehyde
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
NIAID ChemDB
PDB ligand
CompTox Dashboard (EPA)
ECHA InfoCard100.000.323 Edit this at Wikidata
Chemical and physical data
FormulaC21H39N7O12
Molar mass581.580 g·mol−1
3D model (JSmol)
Melting point12 °C (54 °F) [citation needed]
  • CC1C(C(C(O1)OC2C(C(C(C(C2O)O)N=C(N)N)O)N=C(N)N)OC3C(C(C(C(O3)CO)O)O)NC)(C=O)O
  • InChI=1S/C21H39N7O12/c1-5-21(36,4-30)16(40-17-9(26-2)13(34)10(31)6(3-29)38-17)18(37-5)39-15-8(28-20(24)25)11(32)7(27-19(22)23)12(33)14(15)35/h4-18,26,29,31-36H,3H2,1-2H3,(H4,22,23,27)(H4,24,25,28)/t5-,6-,7+,8-,9-,10-,11+,12-,13-,14+,15+,16-,17-,18-,21+/m0/s1 checkY
  • Key:UCSJYZPVAKXKNQ-HZYVHMACSA-N checkY
 ☒NcheckY (what is this?)  (verify)
Look up streptomycin in Wiktionary, the free dictionary.

Streptomycin is an antibiotic medication used to treat a number of bacterial infections,[3] including tuberculosis, Mycobacterium avium complex, endocarditis, brucellosis, Burkholderia infection, plague, tularemia, and rat bite fever.[3] For active tuberculosis it is often given together with isoniazid, rifampicin, and pyrazinamide.[4] It is administered by injection into a vein or muscle.[3]

Common side effects include vertigo, vomiting, numbness of the face, fever, and rash.[3] Use during pregnancy may result in permanent deafness in the developing baby.[3] Use appears to be safe while breastfeeding.[4] It is not recommended in people with myasthenia gravis or other neuromuscular disorders.[4] Streptomycin is an aminoglycoside.[3] It works by blocking the ability of 30S ribosomal subunits to make proteins, which results in bacterial death.[3]

Albert Schatz first isolated streptomycin in 1943 from Streptomyces griseus.[5][6] It is on the World Health Organization's List of Essential Medicines.[7] The World Health Organization classifies it as critically important for human medicine.[8]

  1. ^ "Antibiotic abbreviations list". Retrieved June 22, 2023.
  2. ^ Cite error: The named reference Zhu2001 was invoked but never defined (see the help page).
  3. ^ a b c d e f g "Streptomycin Sulfate". The American Society of Health-System Pharmacists. Archived from the original on December 20, 2016. Retrieved December 8, 2016.
  4. ^ a b c World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. pp. 136, 144, 609. hdl:10665/44053. ISBN 9789241547659.
  5. ^ Torok E, Moran E, Cooke F (2009). Oxford Handbook of Infectious Diseases and Microbiology. OUP Oxford. p. Chapter 2. ISBN 9780191039621. Archived from the original on September 8, 2017.
  6. ^ Renneberg R, Demain AL (2008). Biotechnology for Beginners. Elsevier. p. 103. ISBN 9780123735812. Archived from the original on September 10, 2017.
  7. ^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
  8. ^ World Health Organization (2019). Critically important antimicrobials for human medicine (6th revision ed.). Geneva: World Health Organization. hdl:10665/312266. ISBN 9789241515528. License: CC BY-NC-SA 3.0 IGO.

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