Succimer

Succimer
Clinical data
Pronunciation	/ˈsʌksɪmər/
Trade names	Chemet, others
Other names	Dimercaptosuccinic acid; DMSA; (2R,3S)-2,3-Dimercaptosuccinic acid; meso-2,3-Dimercaptosuccinic acid; APRD01236
AHFS/Drugs.com	Monograph
License data	US DailyMed: Succimer;
ATC code	V03AB (WHO) ;
Legal status
Legal status	US: ℞-only;
Identifiers
	IUPAC name (2R,3S)-2,3-disulfanylbutanedioic acid;
CAS Number	304-55-2 ;
PubChem CID	2724354;
DrugBank	DB00566;
ChemSpider	2006502;
UNII	DX1U2629QE;
KEGG	D00572;
ChEBI	CHEBI:63623;
ChEMBL	ChEMBL1201073;
CompTox Dashboard (EPA)	DTXSID1023601 ;
ECHA InfoCard	100.005.597
Chemical and physical data
Formula	C4H6O4S2
Molar mass	182.21 g·mol−1
3D model (JSmol)	Interactive image;
Melting point	125 °C (257 °F)
	SMILES O=C(O)[C@@H](S)[C@@H](S)C(=O)O;
	InChI InChI=1S/C4H6O4S2/c5-3(6)1(9)2(10)4(7)8/h1-2,9-10H,(H,5,6)(H,7,8)/t1-,2+ ; Key:ACTRVOBWPAIOHC-XIXRPRMCSA-N;

Succimer, sold under the brand name Chemet among others, is a medication used to treat lead, mercury, and arsenic poisoning.^[4] When radiolabeled with technetium-99m, it is used in many types of diagnostic testing.^[5] A full course of Succimer lasts for 19 days of oral administration.^[4] A second course should be given when more than two weeks pass after the first course.^[4]

Common side effects include vomiting, diarrhea, rash, and low blood neutrophil levels.^[4] Liver problems and allergic reactions may also occur with use.^[4] Whether use during pregnancy is safe for the baby is unclear.^[6] Dimercaptosuccinic acid is in the chelating agent family of medications.^[4] It works by binding with lead and a number of other heavy metals, allowing them to leave the body in the urine.^[4]

Succimer has been used medically since the 1950s.^[7]^[8] It is on the World Health Organization's List of Essential Medicines.^[9] In the United States, no generic version was available as of 2015.^[10]

^ "Chemet- succimer capsule". DailyMed. U.S. National Library of Medicine. 12 December 2019. Retrieved 19 June 2022.
^ "Nephroscan- succimer injection, powder, lyophilized, for solution". DailyMed. U.S. National Library of Medicine. 1 March 2022. Retrieved 19 June 2022.
^ "Rotop - DMSA- kit for the preparation of technetium tc99m succimer injection injection, powder, lyophilized, for solution". DailyMed. U.S. National Library of Medicine. 9 March 2021. Retrieved 19 June 2022.
^ ^a ^b ^c ^d ^e ^f ^g "Succimer". The American Society of Health-System Pharmacists. Archived from the original on 16 January 2017. Retrieved 8 January 2017.
^ Biersack HJ, Grünwald F (2005). Thyroid Cancer. Springer Science & Business Media. p. 213. ISBN 9783540278450. Archived from the original on 2017-01-13.
^ "Succimer (Chemet) Use During Pregnancy". www.drugs.com. Archived from the original on 16 January 2017. Retrieved 12 January 2017.
^ Miller AL (June 1998). "Dimercaptosuccinic acid (DMSA), a non-toxic, water-soluble treatment for heavy metal toxicity". Alternative Medicine Review. 3 (3): 199–207. PMID 9630737.
^ Chappell WR, Abernathy CO, Calderon RL (1999). Arsenic Exposure and Health Effects III. Elsevier. p. 350. ISBN 9780080527574. Archived from the original on 2017-01-13.
^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
^ Hamilton R (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 472. ISBN 9781284057560.

[1] "Chemet- succimer capsule". DailyMed. U.S. National Library of Medicine. 12 December 2019. Retrieved 19 June 2022.

[2] "Nephroscan- succimer injection, powder, lyophilized, for solution". DailyMed. U.S. National Library of Medicine. 1 March 2022. Retrieved 19 June 2022.

[3] "Rotop - DMSA- kit for the preparation of technetium tc99m succimer injection injection, powder, lyophilized, for solution". DailyMed. U.S. National Library of Medicine. 9 March 2021. Retrieved 19 June 2022.

[AHFS2017-4] ^ ^a ^b ^c ^d ^e ^f ^g "Succimer". The American Society of Health-System Pharmacists. Archived from the original on 16 January 2017. Retrieved 8 January 2017.

[5] Biersack HJ, Grünwald F (2005). Thyroid Cancer. Springer Science & Business Media. p. 213. ISBN 9783540278450. Archived from the original on 2017-01-13.

[6] "Succimer (Chemet) Use During Pregnancy". www.drugs.com. Archived from the original on 16 January 2017. Retrieved 12 January 2017.

[7] Miller AL (June 1998). "Dimercaptosuccinic acid (DMSA), a non-toxic, water-soluble treatment for heavy metal toxicity". Alternative Medicine Review. 3 (3): 199–207. PMID 9630737.

[8] Chappell WR, Abernathy CO, Calderon RL (1999). Arsenic Exposure and Health Effects III. Elsevier. p. 350. ISBN 9780080527574. Archived from the original on 2017-01-13.

[WHO21st-9] World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.

[Ric2015-10] Hamilton R (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 472. ISBN 9781284057560.

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