Sulfadimethoxine

Sulfadimethoxine

Clinical data
Trade names	Albon, Di-Methox
AHFS/Drugs.com	FDA Professional Drug Information
Routes of administration	By mouth; can be IV in cattle[1]
ATC code	J01ED02 (WHO) QJ01EQ09 (WHO), QP51BA01 (WHO)
Legal status
Legal status	AU: S4 (Prescription only) US: ℞-only (by veterinarian)
Pharmacokinetic data
Bioavailability	55–60%[2]
Elimination half-life	13.1 hours in dogs[2]
Identifiers
IUPAC name 4-Amino-N-(2,6-dimethoxypyrimidin-4-yl)benzenesulfonamide
CAS Number	122-11-2 Y
PubChem CID	5323
DrugBank	DB06150 Y
ChemSpider	5132 Y
UNII	30CPC5LDEX
KEGG	D01142 Y
ChEBI	CHEBI:32161 Y
ChEMBL	ChEMBL62193 Y
CompTox Dashboard (EPA)	DTXSID1023607
ECHA InfoCard	100.004.113
Chemical and physical data
Formula	C12H14N4O4S
Molar mass	310.33 g·mol−1
3D model (JSmol)	Interactive image
SMILES COc1cc(nc(n1)OC)NS(=O)(=O)c2ccc(cc2)N
InChI InChI=1S/C12H14N4O4S/c1-19-11-7-10(14-12(15-11)20-2)16-21(17,18)9-5-3-8(13)4-6-9/h3-7H,13H2,1-2H3,(H,14,15,16) Y Key:ZZORFUFYDOWNEF-UHFFFAOYSA-N Y
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Sulfadimethoxine (or sulphadimethoxine, trade names Di-Methox or Albon) is a long-lasting sulfonamide antimicrobial medication used in veterinary medicine. It is used to treat many infections, including respiratory, urinary tract, enteric, and soft tissue infections^[3] and can be given as a standalone or combined with ormetoprim to broaden the target range.^[2] Like all sulfamides, sulfadimethoxine inhibits bacterial synthesis of folic acid by acting as a competitive inhibitor against PABA. It is the most common drug prescribed to dogs who have coccidiosis.^[4]