Sulindac

Sulindac

Clinical data
Trade names	Clinoril
AHFS/Drugs.com	Monograph
MedlinePlus	a681037
Pregnancy category	AU: C
Routes of administration	By mouth
ATC code	M01AB02 (WHO)
Legal status
Legal status	AU: S4 (Prescription only) UK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Bioavailability	Approximately 90% (Oral)
Metabolism	?
Elimination half-life	7.8 hours, metabolites up to 16.4 hours
Excretion	Renal (50%) and fecal (25%)
Identifiers
IUPAC name {(1Z)-5-fluoro-2-methyl-1-[4-(methylsulfinyl)benzylidene]-1H-indene-3-yl}acetic acid
CAS Number	38194-50-2 Y
PubChem CID	1548887
IUPHAR/BPS	5425
DrugBank	DB00605 Y
ChemSpider	1265915 Y
UNII	184SNS8VUH
KEGG	D00120 Y
ChEBI	CHEBI:9352 Y
ChEMBL	ChEMBL15770 N
PDB ligand	SUZ (PDBe, RCSB PDB)
CompTox Dashboard (EPA)	DTXSID4023624
ECHA InfoCard	100.048.909
Chemical and physical data
Formula	C20H17FO3S
Molar mass	356.41 g·mol−1
3D model (JSmol)	Interactive image
Melting point	182 to 185 °C (360 to 365 °F) (decomp.)
SMILES O=S(c1ccc(cc1)\C=C3/c2ccc(F)cc2\C(=C3C)CC(=O)O)C
InChI InChI=1S/C20H17FO3S/c1-12-17(9-13-3-6-15(7-4-13)25(2)24)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9- Y Key:MLKXDPUZXIRXEP-MFOYZWKCSA-N Y
NY (what is this?)  (verify)

Sulindac is a nonsteroidal anti-inflammatory drug (NSAID) of the arylalkanoic acid class that is marketed as Clinoril. Imbaral (not to be confused with mebaral) is another name for this drug. Its name is derived from sul(finyl)+ ind(ene)+ ac(etic acid) It was patented in 1969 and approved for medical use in 1976.^[1]