| T-cell lymphoma | |
|---|---|
 | |
| Micrograph of an enteropathy-associated T-cell lymphoma (upper right of image), a type of T-cell lymphoma. H&E stain. | |
| Specialty | Hematology and oncology |
| Symptoms | swollen lymph nodes, fevers, enlarged liver or spleen, liver dysfunction, rash |
| Risk factors | Autoimmune disorders, Epstein–Barr virus (EBV), Human T-cell leukemia virus-1 (HTLV1), Organ transplants, immunosuppressant therapy |
| Treatment | chemotherapy, radiotherapy, stem cell transplant |
T-cell lymphoma is a rare form of cancerous lymphoma affecting T-cells.[1] Lymphoma arises mainly from the uncontrolled proliferation of T-cells and can become cancerous.[2]
T-cell lymphoma is categorized under Non-Hodgkin lymphoma (NHL) and represents less than 15% of all Non-Hodgkin's diseases in the category.[3] T-cell lymphomas are often categorised based on their growth patterns as either; aggressive (fast-growing) or indolent (slow-growing).[1] Although the cause of T-cell lymphoma is not definitive, it has been associated with various risk factors and viruses such as Epstein–Barr virus (EBV) and Human T-cell leukemia virus-1 (HTLV1).[2]
The prognosis and treatment of T-cell lymphoma can vary drastically based on the specific type of lymphoma and its growth patterns. Due to their rarity and high variability between the different subtypes, the prognosis of T-cell lymphoma is significantly worse than other Non-Hodgkin lymphoma.[1] The treatment of T-cell lymphoma is often similar to other Non-Hodgkin lymphomas with early-stage treatments consisting of chemotherapy and/or radiotherapy.[2] The effectiveness of these treatments is often varied between subtypes with most receiving a poor outcome with high relapse rates.[4]
- ^ a b c Quesenberry, Peter J.; Castillo, Jorge J. (2013). Non-Hodgkin Lymphoma Prognostic Factors and Targets. NY: Humana Press.
- ^ a b c Foss, Francine (2013). T-cell Lymphomas. Totowa, NJ: Humana Press.
- ^ Querfeld, Christiane; Zain, Jasmine; Rosen, Steven T (2019). T-Cell and NK-Cell Lymphomas From Biology to Novel Therapies. Cham: Springer International Publishing.
- ^ Ansell, Stephen M (2015). "Non-Hodgkin Lymphoma: Diagnosis and Treatment". Mayo Clinic Proceedings. 90 (8): 1152–63. doi:10.1016/j.mayocp.2015.04.025. PMID 26250731.
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