T-cell surface glycoprotein CD3 epsilon chain

CD3E
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1A81, 1SY6, 1XIW, 2ROL
Identifiers
Aliases	CD3E, IMD18, T3E, TCRE, CD3e molecule, CD3epsilon, CD3 epsilon subunit of T-cell receptor complex
External IDs	OMIM: 186830; MGI: 88332; HomoloGene: 586; GeneCards: CD3E; OMA:CD3E - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	118,316,175 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	44,920,925 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; appendix; ; lymph node; ; spleen; ; blood; ; epithelium of colon; ; thymus; ; gallbladder; ; rectum; ; mucosa of transverse colon;
	Top expressed in
	thymus; ; blood; ; morula; ; blastocyst; ; mesenteric lymph nodes; ; spleen; ; pharynx; ; subcutaneous adipose tissue; ; duodenum; ; jejunum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	SH3 domain binding; signal transducer activity; protein binding; protein heterodimerization activity; signaling receptor complex adaptor activity; T cell receptor binding; protein kinase binding; transmembrane signaling receptor activity; protein homodimerization activity;
Cellular component	integral component of membrane; membrane; cell-cell junction; alpha-beta T cell receptor complex; plasma membrane; integral component of plasma membrane; T cell receptor complex; immunological synapse; external side of plasma membrane; dendritic spine; cell body;
Biological process	regulation of apoptotic process; G protein-coupled receptor signaling pathway; positive regulation of calcium-mediated signaling; negative regulation of smoothened signaling pathway; T cell differentiation in thymus; response to nutrient; transmembrane receptor protein tyrosine kinase signaling pathway; immune system process; T cell costimulation; positive regulation of interferon-gamma production; signal complex assembly; negative regulation of gene expression; positive regulation of interleukin-4 production; negative thymic T cell selection; cell surface receptor signaling pathway; positive regulation of gene expression; positive regulation of T cell anergy; positive regulation of T cell activation; positive regulation of T cell proliferation; positive regulation of alpha-beta T cell proliferation; positive regulation of peptidyl-tyrosine phosphorylation; regulation of immune response; apoptotic signaling pathway; lymphocyte activation; T cell receptor signaling pathway; T cell activation; protein homooligomerization; dendrite development; cerebellum development; adaptive immune response; protein-containing complex assembly; positive regulation of cell-matrix adhesion; T cell differentiation; positive regulation of cell-cell adhesion mediated by integrin; positive thymic T cell selection;
	Sources:Amigo / QuickGO
Orthologs
	916
	12501
	ENSG00000198851
	ENSMUSG00000032093
	P07766
	P22646
	NM_000733
	NM_007648
	NP_000724
	NP_031674
	Wikidata
View/Edit Human	View/Edit Mouse

CD3e molecule, epsilon also known as CD3E is a polypeptide which in humans is encoded by the CD3E gene which resides on chromosome 11.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000198851 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032093 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gold DP, Puck JM, Pettey CL, Cho M, Coligan J, Woody JN, Terhorst C (1986). "Isolation of cDNA clones encoding the 20K non-glycosylated polypeptide chain of the human T-cell receptor/T3 complex". Nature. 321 (6068): 431–4. Bibcode:1986Natur.321..431G. doi:10.1038/321431a0. PMID 3012357. S2CID 4318166.
^ Clevers HC, Dunlap S, Wileman TE, Terhorst C (November 1988). "Human CD3-epsilon gene contains three miniexons and is transcribed from a non-TATA promoter". Proceedings of the National Academy of Sciences of the United States of America. 85 (21): 8156–60. doi:10.1073/pnas.85.21.8156. PMC 282386. PMID 3267235.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000198851 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032093 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid3012357-5] Gold DP, Puck JM, Pettey CL, Cho M, Coligan J, Woody JN, Terhorst C (1986). "Isolation of cDNA clones encoding the 20K non-glycosylated polypeptide chain of the human T-cell receptor/T3 complex". Nature. 321 (6068): 431–4. Bibcode:1986Natur.321..431G. doi:10.1038/321431a0. PMID 3012357. S2CID 4318166.

[pmid3267235-6] Clevers HC, Dunlap S, Wileman TE, Terhorst C (November 1988). "Human CD3-epsilon gene contains three miniexons and is transcribed from a non-TATA promoter". Proceedings of the National Academy of Sciences of the United States of America. 85 (21): 8156–60. doi:10.1073/pnas.85.21.8156. PMC 282386. PMID 3267235.

[1]

[2]

[3]

[4]

[5]

[6]