TIMD4

TIMD4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5F7H, 5DZN, 5F7F
Identifiers
Aliases	TIMD4, SMUCKLER, TIM4, T-cell immunoglobulin and mucin domain containing 4, T cell immunoglobulin and mucin domain containing 4
External IDs	OMIM: 610096; MGI: 2445125; HomoloGene: 51381; GeneCards: TIMD4; OMA:TIMD4 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	156,963,226 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	46,735,159 bp
RNA expression pattern
	Top expressed in
	left testis; ; right testis; ; sperm; ; lymph node; ; testicle; ; oocyte; ; trabecular bone; ; synovial joint; ; gonad; ; superficial temporal artery;
	Top expressed in
	spleen; ; secondary oocyte; ; mesenteric lymph nodes; ; zygote; ; primary oocyte; ; subcutaneous adipose tissue; ; mammary gland; ; white adipose tissue; ; embryo; ; liver;
	More reference expression data
	n/a
Orthologs
	91937
	276891
	ENSG00000145850
	ENSMUSG00000055546
	Q96H15
	Q6U7R4
	NM_001146726; NM_138379
	NM_178759
	NP_001140198; NP_612388
	NP_848874
	Wikidata
View/Edit Human	View/Edit Mouse

T-cell immunoglobulin and mucin domain containing 4 (TIMD-4) also known as T-cell membrane protein 4 (TIM-4) is a protein in humans that is encoded by the TIMD4 gene.^[5] TIM-4 genes are in mouse present on chromosome 11B1.1 and in humans on chromosome 5q33.2. TIM-4 contains IgV domain with integrin-binding site as well as a unique metal-ion-dependent ligand binding site for phosphatidylserine.^[6] TIM-4 also contains mucin domain with high levels of O-glycosylation. In comparison to other TIM proteins (such as TIM-1, TIM-2...) it does not contain a tyrosine-phosphorylation motif in its intracellular tail domain.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000145850 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000055546 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: T-cell immunoglobulin and mucin domain containing 4".
^ Santiago C, Ballesteros A, Martínez-Muñoz L, Mellado M, Kaplan GG, Freeman GJ, Casasnovas JM (December 2007). "Structures of T cell immunoglobulin mucin protein 4 show a metal-Ion-dependent ligand binding site where phosphatidylserine binds". Immunity. 27 (6): 941–51. doi:10.1016/j.immuni.2007.11.008. PMC 2330274. PMID 18083575.
^ Meyers JH, Sabatos CA, Chakravarti S, Kuchroo VK (August 2005). "The TIM gene family regulates autoimmune and allergic diseases". Trends in Molecular Medicine. 11 (8): 362–9. doi:10.1016/j.molmed.2005.06.008. PMID 16002337.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000145850 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000055546 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: T-cell immunoglobulin and mucin domain containing 4".

[6] Santiago C, Ballesteros A, Martínez-Muñoz L, Mellado M, Kaplan GG, Freeman GJ, Casasnovas JM (December 2007). "Structures of T cell immunoglobulin mucin protein 4 show a metal-Ion-dependent ligand binding site where phosphatidylserine binds". Immunity. 27 (6): 941–51. doi:10.1016/j.immuni.2007.11.008. PMC 2330274. PMID 18083575.

[Meyers_2005-7] Meyers JH, Sabatos CA, Chakravarti S, Kuchroo VK (August 2005). "The TIM gene family regulates autoimmune and allergic diseases". Trends in Molecular Medicine. 11 (8): 362–9. doi:10.1016/j.molmed.2005.06.008. PMID 16002337.

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