TNFRSF12A

TNFRSF12A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2EQP, 2KMZ, 2RPJ
Identifiers
Aliases	TNFRSF12A, CD266, FN14, TWEAKR, tumor necrosis factor receptor superfamily member 12A, TNF receptor superfamily member 12A
External IDs	OMIM: 605914; MGI: 1351484; HomoloGene: 8451; GeneCards: TNFRSF12A; OMA:TNFRSF12A - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	3,022,383 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	23,896,442 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; ascending aorta; ; body of pancreas; ; beta cell; ; anterior pituitary; ; gallbladder; ; right coronary artery; ; upper lobe of left lung; ; left ventricle; ; Descending thoracic aorta;
	Top expressed in
	interventricular septum; ; decidua; ; muscle of thigh; ; adrenal gland; ; soleus muscle; ; endothelial cell of lymphatic vessel; ; lip; ; yolk sac; ; right ventricle; ; gastrula;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	ruffle; integral component of membrane; cell surface; plasma membrane; membrane;
Biological process	apoptotic process; substrate-dependent cell migration, cell attachment to substrate; multicellular organism development; positive regulation of extrinsic apoptotic signaling pathway; cell differentiation; positive regulation of axon extension; cell adhesion; tumor necrosis factor-mediated signaling pathway; regulation of wound healing; regulation of angiogenesis; extrinsic apoptotic signaling pathway; angiogenesis; positive regulation of apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	51330
	27279
	ENSG00000006327
	ENSMUSG00000023905
	Q9NP84
	Q9CR75
	NM_016639
	NM_001161746; NM_013749
	NP_057723
	NP_001155218; NP_038777
	Wikidata
View/Edit Human	View/Edit Mouse

Tumor necrosis factor receptor superfamily member 12A also known as the TWEAK receptor (TWEAKR) is a protein that in humans is encoded by the TNFRSF12A gene.^[5]^[6]^[7]

Other names used when talking about TNFRSF12A are fibroblast growth factor-inducible immediate-early response protein 14 (FN14).^[8] TNFRSF12A is a unique member of the Tumor Necrosis Factor Receptor superfamily. TNFRSF12A is the smallest member of the Tumor Necrosis Factor Receptor superfamily^[8] and the gene expression is highly regulated in a live organism and a petri dish.^[9] TNFRSF12A is the receptor for the TWEAK which is its ligand.^[8] Many other members of the Tumor necrosis factor superfamily can bind to other ligands but this receptor can only bind to TNFRSF12.^[10] TNFRSF12A is found in many human tissues, including the heart, placenta, lung, skeletal muscle, kidney, and pancreas. It is involved in several biological processes, such as inflammatory reactions, angiogenesis, cell proliferation, and cell death.^[11]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000006327 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000023905 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Feng SL, Guo Y, Factor VM, Thorgeirsson SS, Bell DW, Testa JR, et al. (April 2000). "The Fn14 immediate-early response gene is induced during liver regeneration and highly expressed in both human and murine hepatocellular carcinomas". The American Journal of Pathology. 156 (4): 1253–1261. doi:10.1016/S0002-9440(10)64996-6. PMC 1876890. PMID 10751351.
^ Meighan-Mantha RL, Hsu DK, Guo Y, Brown SA, Feng SL, Peifley KA, et al. (November 1999). "The mitogen-inducible Fn14 gene encodes a type I transmembrane protein that modulates fibroblast adhesion and migration". The Journal of Biological Chemistry. 274 (46): 33166–33176. doi:10.1074/jbc.274.46.33166. PMID 10551889.
^ "Entrez Gene: TNFRSF12A tumor necrosis factor receptor superfamily, member 12A".
^ ^a ^b ^c Winkles JA (May 2008). "The TWEAK-Fn14 cytokine-receptor axis: discovery, biology and therapeutic targeting". Nature Reviews. Drug Discovery. 7 (5): 411–425. doi:10.1038/nrd2488. PMC 3018765. PMID 18404150.
^ Cite error: The named reference Ruiz_2023 was invoked but never defined (see the help page).
^ Perez JG, Tran NL, Rosenblum MG, Schneider CS, Connolly NP, Kim AJ, et al. (April 2016). "The TWEAK receptor Fn14 is a potential cell surface portal for targeted delivery of glioblastoma therapeutics". Oncogene. 35 (17): 2145–2155. doi:10.1038/onc.2015.310. PMC 4850525. PMID 26300004.
^ Cite error: The named reference Liao_2023 was invoked but never defined (see the help page).

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000006327 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000023905 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10751351-5] Feng SL, Guo Y, Factor VM, Thorgeirsson SS, Bell DW, Testa JR, et al. (April 2000). "The Fn14 immediate-early response gene is induced during liver regeneration and highly expressed in both human and murine hepatocellular carcinomas". The American Journal of Pathology. 156 (4): 1253–1261. doi:10.1016/S0002-9440(10)64996-6. PMC 1876890. PMID 10751351.

[Meighan-Mantha_1999-6] Meighan-Mantha RL, Hsu DK, Guo Y, Brown SA, Feng SL, Peifley KA, et al. (November 1999). "The mitogen-inducible Fn14 gene encodes a type I transmembrane protein that modulates fibroblast adhesion and migration". The Journal of Biological Chemistry. 274 (46): 33166–33176. doi:10.1074/jbc.274.46.33166. PMID 10551889.

[entrez-7] "Entrez Gene: TNFRSF12A tumor necrosis factor receptor superfamily, member 12A".

[Winkles_2008_2-8] Winkles JA (May 2008). "The TWEAK-Fn14 cytokine-receptor axis: discovery, biology and therapeutic targeting". Nature Reviews. Drug Discovery. 7 (5): 411–425. doi:10.1038/nrd2488. PMC 3018765. PMID 18404150.

[Ruiz_2023-9] Cite error: The named reference Ruiz_2023 was invoked but never defined (see the help page).

[10] Perez JG, Tran NL, Rosenblum MG, Schneider CS, Connolly NP, Kim AJ, et al. (April 2016). "The TWEAK receptor Fn14 is a potential cell surface portal for targeted delivery of glioblastoma therapeutics". Oncogene. 35 (17): 2145–2155. doi:10.1038/onc.2015.310. PMC 4850525. PMID 26300004.

[Liao_2023-11] Cite error: The named reference Liao_2023 was invoked but never defined (see the help page).

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