TNFSF12

TNFSF12
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4HT1
Identifiers
Aliases	TNFSF12, APO3L, DR3LG, TWEAK, TNLG4A, tumor necrosis factor superfamily member 12, TNF superfamily member 12
External IDs	OMIM: 602695; MGI: 1196259; HomoloGene: 7979; GeneCards: TNFSF12; OMA:TNFSF12 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	7,557,890 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	69,586,675 bp
RNA expression pattern
	Top expressed in
	right coronary artery; ; thoracic aorta; ; ascending aorta; ; Descending thoracic aorta; ; left coronary artery; ; popliteal artery; ; tibial arteries; ; gastric mucosa; ; muscle layer of sigmoid colon; ; apex of heart;
	Top expressed in
	neural layer of retina; ; tunica media of zone of aorta; ; lip; ; ankle; ; right lung; ; ascending aorta; ; stroma of bone marrow; ; aortic valve; ; lactiferous gland; ; muscle of thigh;
	More reference expression data
	n/a
Gene ontology
Molecular function	cytokine activity; protein binding; tumor necrosis factor receptor binding; signaling receptor binding;
Cellular component	integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; extracellular region; perinuclear region of cytoplasm; extracellular space;
Biological process	cell differentiation; positive regulation of endothelial cell proliferation; positive regulation of protein catabolic process; extrinsic apoptotic signaling pathway; tumor necrosis factor-mediated signaling pathway; positive regulation of angiogenesis; multicellular organism development; angiogenesis; immune response; apoptotic signaling pathway; positive regulation of extrinsic apoptotic signaling pathway; endothelial cell migration; signal transduction; apoptotic process; regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	8742
	21944
	ENSG00000239697
	ENSMUSG00000097328
	O43508
	O54907
	NM_003809
	NM_011614
	NP_003800
	NP_035744
	Wikidata
View/Edit Human	View/Edit Mouse

Tumor necrosis factor ligand superfamily member 12 also known as TNF-related weak inducer of apoptosis (TWEAK) is a protein that in humans is encoded by the TNFSF12 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000239697 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000097328 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Chicheportiche Y, Bourdon PR, Xu H, Hsu YM, Scott H, Hession C, Garcia I, Browning JL (December 1997). "TWEAK, a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis". The Journal of Biological Chemistry. 272 (51): 32401–10. doi:10.1074/jbc.272.51.32401. PMID 9405449.
^ Marsters SA, Sheridan JP, Pitti RM, Brush J, Goddard A, Ashkenazi A (April 1998). "Identification of a ligand for the death-domain-containing receptor Apo3". Current Biology. 8 (9): 525–8. Bibcode:1998CBio....8..525M. doi:10.1016/S0960-9822(98)70204-0. PMID 9560343. S2CID 14953579.
^ "Entrez Gene: TNFSF12 tumor necrosis factor (ligand) superfamily, member 12".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000239697 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000097328 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9405449-5] Chicheportiche Y, Bourdon PR, Xu H, Hsu YM, Scott H, Hession C, Garcia I, Browning JL (December 1997). "TWEAK, a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis". The Journal of Biological Chemistry. 272 (51): 32401–10. doi:10.1074/jbc.272.51.32401. PMID 9405449.

[pmid9560343-6] Marsters SA, Sheridan JP, Pitti RM, Brush J, Goddard A, Ashkenazi A (April 1998). "Identification of a ligand for the death-domain-containing receptor Apo3". Current Biology. 8 (9): 525–8. Bibcode:1998CBio....8..525M. doi:10.1016/S0960-9822(98)70204-0. PMID 9560343. S2CID 14953579.

[entrez-7] "Entrez Gene: TNFSF12 tumor necrosis factor (ligand) superfamily, member 12".

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