TRAF3

TRAF3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1FLK, 1FLL, 1KZZ, 1L0A, 1RF3, 1ZMS, 2ECY, 2GKW
Identifiers
Aliases	TRAF3, CAP-1, CAP1, CD40bp, CRAF1, IIAE5, LAP1, TNF receptor associated factor 3, RNF118
External IDs	OMIM: 601896; MGI: 108041; HomoloGene: 7981; GeneCards: TRAF3; OMA:TRAF3 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	102,911,500 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	111,233,587 bp
RNA expression pattern
	Top expressed in
	cartilage tissue; ; monocyte; ; Brodmann area 46; ; appendix; ; middle temporal gyrus; ; granulocyte; ; postcentral gyrus; ; lymph node; ; testicle; ; tibia;
	Top expressed in
	CA3 field; ; vestibular sensory epithelium; ; ventral tegmental area; ; Epithelium of choroid plexus; ; central gray substance of midbrain; ; entorhinal cortex; ; subiculum; ; dorsomedial hypothalamic nucleus; ; lacrimal gland; ; superior colliculus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	zinc ion binding; signal transducer activity; metal ion binding; protein binding; thioesterase binding; protein phosphatase binding; protein kinase binding; ubiquitin protein ligase binding; transferase activity; ubiquitin-protein transferase activity; tumor necrosis factor receptor binding;
Cellular component	cytoplasm; cytosol; endosome; mitochondrion; cytoplasmic side of plasma membrane; CD40 receptor complex; protein-containing complex;
Biological process	regulation of apoptotic process; Toll signaling pathway; immune system process; TRIF-dependent toll-like receptor signaling pathway; protein ubiquitination; negative regulation of NF-kappaB transcription factor activity; regulation of proteolysis; apoptotic process; toll-like receptor signaling pathway; regulation of cytokine production; signal transduction; regulation of interferon-beta production; innate immune response; tumor necrosis factor-mediated signaling pathway; regulation of defense response to virus; protein deubiquitination;
	Sources:Amigo / QuickGO
Orthologs
	7187
	22031
	ENSG00000131323
	ENSMUSG00000021277
	Q13114
	Q60803
NM_001199427; NM_003300; NM_145725; NM_145726; NM_001385142;
	NM_001385143
	NM_001048206; NM_001286122; NM_011632; NM_001364364
	NP_001186356; NP_003291; NP_663777; NP_663778
	NP_001273051; NP_035762; NP_001351293
	Wikidata
View/Edit Human	View/Edit Mouse

TNF receptor-associated factor (TRAF3) is a protein that in humans is encoded by the TRAF3 gene. ^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000131323 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021277 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Cheng G, Cleary AM, Ye ZS, Hong DI, Lederman S, Baltimore D (March 1995). "Involvement of CRAF1, a relative of TRAF, in CD40 signaling". Science. 267 (5203): 1494–8. Bibcode:1995Sci...267.1494C. doi:10.1126/science.7533327. PMID 7533327. S2CID 39062705.
^ Sato T, Irie S, Reed JC (January 1995). "A novel member of the TRAF family of putative signal transducing proteins binds to the cytosolic domain of CD40". FEBS Letters. 358 (2): 113–8. doi:10.1016/0014-5793(94)01406-Q. PMID 7530216. S2CID 36111713.
^ Mosialos G, Birkenbach M, Yalamanchili R, VanArsdale T, Ware C, Kieff E (February 1995). "The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family". Cell. 80 (3): 389–99. doi:10.1016/0092-8674(95)90489-1. PMID 7859281.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000131323 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021277 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Cheng G, Cleary AM, Ye ZS, Hong DI, Lederman S, Baltimore D (March 1995). "Involvement of CRAF1, a relative of TRAF, in CD40 signaling". Science. 267 (5203): 1494–8. Bibcode:1995Sci...267.1494C. doi:10.1126/science.7533327. PMID 7533327. S2CID 39062705.

[pmid7530216-6] Sato T, Irie S, Reed JC (January 1995). "A novel member of the TRAF family of putative signal transducing proteins binds to the cytosolic domain of CD40". FEBS Letters. 358 (2): 113–8. doi:10.1016/0014-5793(94)01406-Q. PMID 7530216. S2CID 36111713.

[pmid7859281-7] Mosialos G, Birkenbach M, Yalamanchili R, VanArsdale T, Ware C, Kieff E (February 1995). "The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family". Cell. 80 (3): 389–99. doi:10.1016/0092-8674(95)90489-1. PMID 7859281.

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