TREM1

TREM1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1Q8M, 1SMO
Identifiers
Aliases	TREM1, CD354, TREM-1, triggering receptor expressed on myeloid cells 1
External IDs	OMIM: 605085; MGI: 1930005; HomoloGene: 10243; GeneCards: TREM1; OMA:TREM1 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	41,286,682 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	48,553,952 bp
RNA expression pattern
	Top expressed in
	monocyte; ; periodontal fiber; ; blood; ; right lung; ; upper lobe of left lung; ; granulocyte; ; lower lobe of lung; ; decidua; ; bone marrow; ; bone marrow cells;
	Top expressed in
	granulocyte; ; bone marrow; ; embryo; ; zygote; ; embryo; ; secondary oocyte; ; primary oocyte; ; spermatid; ; lung; ; spleen;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	scaffold protein binding; signaling receptor activity;
Cellular component	integral component of membrane; membrane; plasma membrane; extracellular region; intracellular anatomical structure;
Biological process	intracellular signal transduction; humoral immune response; regulation of immune response; innate immune response; leukocyte migration; acute inflammatory response;
	Sources:Amigo / QuickGO
Orthologs
	54210
	58217
	ENSG00000124731
	ENSMUSG00000042265
	Q9NP99
	Q9JKE2
	NM_001242589; NM_001242590; NM_018643
	NM_021406; NM_001347399
	NP_001229518; NP_001229519; NP_061113
	NP_001334328; NP_067381
	Wikidata
View/Edit Human	View/Edit Mouse

Triggering receptor expressed on myeloid cells 1 (TREM1) is an immunoglobulin (Ig) superfamily transmembrane protein that, in humans, is encoded by the TREM1 gene.^[5]^[6]^[7] TREM1 is constitutively expressed on the surface of peripheral blood monocytes and neutrophils, and upregulated by toll-like receptor (TLR) ligands; activation of TREM1 amplifies immune responses.^[6]^[8]^[9]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000124731 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000042265 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gingras MC, Lapillonne H, Margolin JF (March 2002). "TREM-1, MDL-1, and DAP12 expression is associated with a mature stage of myeloid development". Molecular Immunology. 38 (11): 817–24. doi:10.1016/S0161-5890(02)00004-4. PMID 11922939.
^ ^a ^b Bouchon A, Dietrich J, Colonna M (May 2000). "Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes". Journal of Immunology. 164 (10): 4991–5. doi:10.4049/jimmunol.164.10.4991. PMID 10799849.
^ "Entrez Gene: TREM1 triggering receptor expressed on myeloid cells 1".
^ Cite error: The named reference :0 was invoked but never defined (see the help page).
^ Mabbott NA, Baillie J, Brown H, Freeman TC, Hume DA (2013). "An expression atlas of human primary cells: inference of gene function from coexpression networks". BMC Genomics. 14 (1): 632. doi:10.1186/1471-2164-14-632. ISSN 1471-2164. PMC 3849585. PMID 24053356.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000124731 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000042265 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11922939-5] Gingras MC, Lapillonne H, Margolin JF (March 2002). "TREM-1, MDL-1, and DAP12 expression is associated with a mature stage of myeloid development". Molecular Immunology. 38 (11): 817–24. doi:10.1016/S0161-5890(02)00004-4. PMID 11922939.

[pmid10799849-6] Bouchon A, Dietrich J, Colonna M (May 2000). "Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes". Journal of Immunology. 164 (10): 4991–5. doi:10.4049/jimmunol.164.10.4991. PMID 10799849.

[entrez-7] "Entrez Gene: TREM1 triggering receptor expressed on myeloid cells 1".

[:0-8] Cite error: The named reference :0 was invoked but never defined (see the help page).

[9] Mabbott NA, Baillie J, Brown H, Freeman TC, Hume DA (2013). "An expression atlas of human primary cells: inference of gene function from coexpression networks". BMC Genomics. 14 (1): 632. doi:10.1186/1471-2164-14-632. ISSN 1471-2164. PMC 3849585. PMID 24053356.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]