Telmisartan

Telmisartan
Clinical data
Pronunciation	/tɛlmɪˈsɑːrtən/
Trade names	Micardis, Actavis, others
AHFS/Drugs.com	Monograph
MedlinePlus	a601249
License data	US DailyMed: Telmisartan;
Pregnancy; category	AU: D; ;
Routes of; administration	By mouth
Drug class	Angiotensin II receptor antagonist
ATC code	C09CA07 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only); CA: ℞-only; UK: POM (Prescription only); US: WARNINGRx-only; EU: Rx-only;
Pharmacokinetic data
Bioavailability	42–100%
Protein binding	>99.5%
Metabolism	Minimal liver (glucuronidation)
Elimination half-life	24 hours
Excretion	Feces 97%
Identifiers
	IUPAC name 2-(4-{[4-Methyl-6-(1-methyl-1H-1,3-benzodiazol-2-yl)-2-propyl-1H-1,3-benzodiazol-1-yl]methyl}phenyl)benzoic acid;
CAS Number	144701-48-4 ;
PubChem CID	65999;
IUPHAR/BPS	592;
DrugBank	DB00966 ;
ChemSpider	59391 ;
UNII	U5SYW473RQ;
KEGG	D00627 ;
ChEBI	CHEBI:9434 ;
ChEMBL	ChEMBL1017 ;
CompTox Dashboard (EPA)	DTXSID8023636 ;
ECHA InfoCard	100.149.347
Chemical and physical data
Formula	C33H30N4O2
Molar mass	514.629 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(O)c1ccccc1c2ccc(cc2)Cn3c4cc(cc(c4nc3CCC)C)c5nc6ccccc6n5C;
	InChI InChI=1S/C33H30N4O2/c1-4-9-30-35-31-21(2)18-24(32-34-27-12-7-8-13-28(27)36(32)3)19-29(31)37(30)20-22-14-16-23(17-15-22)25-10-5-6-11-26(25)33(38)39/h5-8,10-19H,4,9,20H2,1-3H3,(H,38,39) ; Key:RMMXLENWKUUMAY-UHFFFAOYSA-N ;
	(verify)

Telmisartan, sold under the brand name Micardis among others, is a medication used to treat high blood pressure, heart failure, and diabetic kidney disease.^[3] It is a reasonable initial treatment for high blood pressure.^[3] It is taken by mouth.^[3] Versions are available as the combination^[4] telmisartan/hydrochlorothiazide, telmisartan/cilnidipine^[5] and telmisartan/amlodipine.^[3]

Common side effects include upper respiratory tract infections, diarrhea, and back pain.^[3] Serious side effects may include kidney problems, low blood pressure, and angioedema.^[3] Use in pregnancy may harm the baby and use when breastfeeding is not recommended.^[6] It is an angiotensin II receptor antagonist and works by blocking the effects of angiotensin II.^[3]

Telmisartan was patented in 1991 and came into medical use in 1999.^[7] It is available as a generic medication.^[8] In 2021, it was the 217th most commonly prescribed medication in the United States, with more than 1 million prescriptions.^[9]^[10]

^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 October 2023.
^ "Semintra EPAR". European Medicines Agency. 28 February 2013. Retrieved 26 June 2024.
^ ^a ^b ^c ^d ^e ^f ^g "Telmisartan Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 3 March 2019.
^ Golwala D. "Formulation and Evaluation of Mouth Dissolving Tablets of Telmisartan". Inventi Journals. Retrieved 18 July 2020.^{[permanent dead link]}
^ "Cilacar T". Medical Dialogues. Retrieved 23 February 2021.
^ "Telmisartan Pregnancy and Breastfeeding Warnings". Drugs.com. Retrieved 3 March 2019.
^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 471. ISBN 9783527607495.
^ British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 178. ISBN 9780857113382.
^ "The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
^ "Telmisartan - Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.

[FDA-AllBoxedWarnings-1] "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 October 2023.

[2] "Semintra EPAR". European Medicines Agency. 28 February 2013. Retrieved 26 June 2024.

[AHFS2019-3] ^ ^a ^b ^c ^d ^e ^f ^g "Telmisartan Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 3 March 2019.

[4] Golwala D. "Formulation and Evaluation of Mouth Dissolving Tablets of Telmisartan". Inventi Journals. Retrieved 18 July 2020.^{[permanent dead link]}

[5] "Cilacar T". Medical Dialogues. Retrieved 23 February 2021.

[Preg2019-6] "Telmisartan Pregnancy and Breastfeeding Warnings". Drugs.com. Retrieved 3 March 2019.

[Fis2006-7] Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 471. ISBN 9783527607495.

[BNF76-8] British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 178. ISBN 9780857113382.

[9] "The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.

[10] "Telmisartan - Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.

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