Testicular cancer | |
---|---|
Other names | Testis tumor[1] |
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7.4 × 5.5-cm seminoma in a radical orchiectomy specimen. | |
Specialty | Oncology |
Symptoms | Lump in the testicle, swelling or pain in the scrotum[2] |
Usual onset | 20 to 34 years old males[3] |
Types | Germ cell tumors (seminomas and nonseminomas), sex-cord stromal tumors, lymphomas[4][5] |
Risk factors | Undescended testis, family history of the disease, previous history of testicular cancer[5] |
Diagnostic method | Physical exam, ultrasound, blood tests, surgical removal of the testicle[2] |
Differential diagnosis | Spermatocele, epididymitis, inguinal hernia, appendix testis[1] |
Treatment | Surgery, radiation therapy, chemotherapy, stem cell transplantation[2] |
Prognosis | Five-year survival rate rates ~ 95% (US)[3] |
Frequency | 686,000 (2015)[6] |
Deaths | 9,400 (2015)[7] |
Testicular cancer is cancer that develops in the testicles, a part of the male reproductive system.[2] Symptoms may include a lump in the testicle or swelling or pain in the scrotum.[2] Treatment may result in infertility.[2]
Risk factors include an undescended testis, family history of the disease, and previous history of testicular cancer.[5] More than 95% are germ cell tumors which are divided into seminomas and non-seminomas.[8] Other types include sex-cord stromal tumors and lymphomas.[4] Diagnosis is typically based on a physical exam, ultrasound, and blood tests.[2] Surgical removal of the testicle with examination under a microscope is then done to determine the type.[2]
Testicular cancer is highly treatable and usually curable.[5] Treatment options may include surgery, radiation therapy, chemotherapy, or stem cell transplantation.[2] Even in cases in which cancer has spread widely, chemotherapy offers a cure rate greater than 80%.[4]
Globally testicular cancer affected about 686,000 people in 2015.[6] That year it resulted in 9,400 deaths up from 7,000 deaths in 1990.[7][9] Rates are lower in the developing than the developed world.[10] Onset most commonly occurs in males 20 to 34 years old, rarely before 15 years old.[3][11] The five-year survival rate in the United States is about 95%.[3] Outcomes are better when the disease remains localized.[3]
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