Tetherin

BST2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2LK9, 2X7A, 2XG7, 3MQ7, 3MQ9, 3MQB, 3MQC, 3NWH, 4P6Z
Identifiers
Aliases	BST2, CD317, TETHERIN, Tetherin, bone marrow stromal cell antigen 2, HM1.24
External IDs	OMIM: 600534; MGI: 1916800; HomoloGene: 48277; GeneCards: BST2; OMA:BST2 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	17,405,630 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	71,990,100 bp
RNA expression pattern
	Top expressed in
	right adrenal gland; ; right adrenal cortex; ; left adrenal cortex; ; left ovary; ; right ovary; ; left uterine tube; ; monocyte; ; granulocyte; ; spleen; ; right uterine tube;
	Top expressed in
	left lobe of liver; ; yolk sac; ; stroma of bone marrow; ; endothelial cell of lymphatic vessel; ; mucous cell of stomach; ; thymus; ; interventricular septum; ; uterus; ; subcutaneous adipose tissue; ; mesenteric lymph nodes;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; signal transducer activity; protein binding; metalloendopeptidase inhibitor activity; RNA binding; identical protein binding;
Cellular component	cytoplasm; integral component of membrane; multivesicular body; endosome; late endosome; Golgi apparatus; membrane; plasma membrane; integral component of plasma membrane; cell surface; apical plasma membrane; membrane raft; anchored component of membrane; extracellular exosome; cytosol; azurophil granule membrane;
Biological process	negative regulation of intracellular transport of viral material; regulation of actin cytoskeleton organization; response to interferon-gamma; immune system process; cell-cell signaling; response to virus; response to interferon-beta; multicellular organism development; B cell activation; negative regulation of viral genome replication; negative regulation of cell migration; humoral immune response; defense response to virus; type I interferon signaling pathway; negative regulation of cell growth; negative regulation of plasmacytoid dendritic cell cytokine production; response to interferon-alpha; positive regulation of I-kappaB kinase/NF-kappaB signaling; cell population proliferation; innate immune response; negative regulation of endopeptidase activity; neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologs
	684
	69550
	ENSG00000130303
	ENSMUSG00000046718
	Q10589
	Q8R2Q8
	NM_004335
	NM_198095
	NP_004326
	NP_932763
	Wikidata
View/Edit Human	View/Edit Mouse

Tetherin, also known as bone marrow stromal antigen 2, is a lipid raft associated protein that in humans is encoded by the BST2 gene.^[5]^[6]^[7] In addition, tetherin has been designated as CD317 (cluster of differentiation 317). This protein is constitutively expressed in mature B cells, plasma cells and plasmacytoid dendritic cells, and in many other cells, it is only expressed as a response to stimuli from IFN pathway.^[8]^[9]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000130303 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000046718 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ishikawa J, Kaisho T, Tomizawa H, Lee BO, Kobune Y, Inazawa J, et al. (April 1995). "Molecular cloning and chromosomal mapping of a bone marrow stromal cell surface gene, BST2, that may be involved in pre-B-cell growth". Genomics. 26 (3): 527–534. doi:10.1016/0888-7543(95)80171-H. PMID 7607676.
^ "Entrez Gene: BST2 bone marrow stromal cell antigen 2".
^ Rollason R, Korolchuk V, Hamilton C, Schu P, Banting G (November 2007). "Clathrin-mediated endocytosis of a lipid-raft-associated protein is mediated through a dual tyrosine motif". Journal of Cell Science. 120 (Pt 21): 3850–3858. doi:10.1242/jcs.003343. PMID 17940069.
^ Le Tortorec A, Willey S, Neil SJ (May 2011). "Antiviral inhibition of enveloped virus release by tetherin/BST-2: action and counteraction". Viruses. 3 (5): 520–540. doi:10.3390/v3050520. PMC 3185764. PMID 21994744.
^ El-Sherbiny YM, Md Yusof MY, Psarras A, Hensor EM, Kabba KZ, Dutton K, et al. (May 2020). "B Cell Tetherin: A Flow Cytometric Cell-Specific Assay for Response to Type I Interferon Predicts Clinical Features and Flares in Systemic Lupus Erythematosus". Arthritis & Rheumatology. 72 (5): 769–779. doi:10.1002/art.41187. PMC 8653884. PMID 31804007.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000130303 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000046718 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7607676-5] Ishikawa J, Kaisho T, Tomizawa H, Lee BO, Kobune Y, Inazawa J, et al. (April 1995). "Molecular cloning and chromosomal mapping of a bone marrow stromal cell surface gene, BST2, that may be involved in pre-B-cell growth". Genomics. 26 (3): 527–534. doi:10.1016/0888-7543(95)80171-H. PMID 7607676.

[entrez-6] "Entrez Gene: BST2 bone marrow stromal cell antigen 2".

[Rollason-7] Rollason R, Korolchuk V, Hamilton C, Schu P, Banting G (November 2007). "Clathrin-mediated endocytosis of a lipid-raft-associated protein is mediated through a dual tyrosine motif". Journal of Cell Science. 120 (Pt 21): 3850–3858. doi:10.1242/jcs.003343. PMID 17940069.

[Tortorec-8] Le Tortorec A, Willey S, Neil SJ (May 2011). "Antiviral inhibition of enveloped virus release by tetherin/BST-2: action and counteraction". Viruses. 3 (5): 520–540. doi:10.3390/v3050520. PMC 3185764. PMID 21994744.

[pmid31804007-9] El-Sherbiny YM, Md Yusof MY, Psarras A, Hensor EM, Kabba KZ, Dutton K, et al. (May 2020). "B Cell Tetherin: A Flow Cytometric Cell-Specific Assay for Response to Type I Interferon Predicts Clinical Features and Flares in Systemic Lupus Erythematosus". Arthritis & Rheumatology. 72 (5): 769–779. doi:10.1002/art.41187. PMC 8653884. PMID 31804007.

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