Theodosius II was the eastern Roman emperor from 402 until 450.
Theodosius II or Theodosios II may also refer to:
- Theodosius II of Abkhazia, king 828–855
- Theodosius II of Alexandria, patriarch 12th century
- Teodósio II, Duke of Braganza, duke of Braganza (1583-1630) and father of John IV of Portugal
- Theodosius II of Constantinople, patriarch 1769–1773
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