Thermopylae is a mountain passage in central Greece.
Thermopylae may also refer to:
- Thermopylae (clipper), an extreme composite clipper ship built 1868
- HMS Thermopylae (P355), Royal Navy submarine launched in 1945
- Thermopylae, a poem written by the Greek poet Constantine P. Cavafy
- Thermopylae, North Carolina, the fictional setting of Michael Malone's novel, Handling Sin
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